High sodium intake strengthens the association between angiotensinogen T174M polymorphism and blood pressure levels among lean men and women: a community-based study.
High sodium intake strengthens the association between angiotensinogen T174M polymorphism and blood pressure levels among lean men and women: a community-based study.
复制标题
高钠摄入量增强了瘦男性和女性血管紧张素原 T174M 多态性与血压水平之间的关联：一项基于社区的研究。
作者：
K. Yamagishi;Hiroyasu Iso;Takeshi Tanigawa;R. Cui;M. Kudo;T. Shimamoto
盐摄入量对血管紧张素原（AGT）T174 M多态性和高血压之间相互作用的影响的证据很少。因此，我们在日本农业社区对2，823名年龄在30-74岁的男性和女性进行了一项大型基于人群的横断面研究，以检查AGT多态性与按年龄（30-64岁和65-74岁）分层的血压水平、体重指数（BMI;中位数）和盐摄入量（中位数）之间的关联，这些血压水平通过24小时尿液收集和饮食问卷进行估计。我们的先验假设是，具有174 M等位基因的个体，特别是年轻和非超重个体，在响应较高的钠摄入量时血压水平升高，因此T174 M多态性和血压之间的关联在高钠摄入量的个体中比低钠摄入量的个体更明显。总体而言，TT和TM+MM基因型组之间的收缩压或舒张压水平（SBP或DBP）没有差异。然而，TM+MM组和TT组之间的DBP平均差异在年轻受试者中为+1.0 mmHg（p=0.06），在非超重受试者中为+1.7 mmHg（BMI<23.5 kg/m2，p=0.01），在年轻和非超重受试者中为+2.3 mmHg（p = 0.002）。此外，在年轻和非超重的受试者中，尿钠排泄量较高者的血压差异较大（+3.1 mmHg，p = 0.03），钠/钾排泄率较高的患者（+4.1 mmHg，p=0.007），目前钠摄入评分较高的患者（+3.0 mmHg，p=0.003）和既往钠摄入评分较高的患者（+3.4 mmHg，p<0.001）。总之，AGT T174 M多态性与年轻和非超重日本人的较高DBP水平相关。这种关联在钠摄入量较高的受试者中更为明显。
Evidence on the effect of salt intake on the interaction between angiotensinogen (AGT) T174M polymorphism and high blood pressure is sparse. We therefore conducted a large population-based cross-sectional study of 2,823 men and women aged 30-74 in a Japanese farming community to examine associations between AGT polymorphism and blood pressure levels stratified by age (30-64 and 65-74), body mass index (BMI; median), and salt intake (median) estimated by 24-h urine collection and dietary questionnaire. Our a priori hypothesis is that individuals, particularly younger and non-overweight individuals, with the 174M allele have elevated blood pressure levels in response to higher sodium intake, and thus the association between T174M polymorphism and blood pressure is more evident among individuals with higher sodium intake than those with lower sodium intake. There were no differences in systolic or diastolic blood pressure levels (SBP or DBP) between the TT and TM+MM genotype groups overall. However, the mean difference in DBP between the TM+MM and TT groups was +1.0 mmHg in subjects of younger age (p=0.06), +1.7 mmHg in non-overweight subjects (BMI<23.5 kg/m2, p=0.01), and +2.3 mmHg in younger and non-overweight subjects (p = 0.002). Furthermore, among younger and non-overweight subjects, blood pressure differences were larger for those with higher urinary sodium excretion (+3.1 mmHg, p = 0.03), those with a higher sodium/potassium excretion ratio (+4.1 mmHg, p=0.007), those with higher present sodium intake score (+3.0 mmHg, p=0.003), and those with higher past sodium intake score (+3.4 mmHg, p<0.001). In conclusion, AGT T174M polymorphism was associated with higher DBP levels in younger and non-overweight Japanese. This association was more evident among subjects with higher sodium intake.
影响因子：
9.8
作者：
Jeunemaitre, X;Inoue, I;Lalouel, JM
通讯作者：
Lalouel, JM