RHODAMINE-123 SELECTIVELY REDUCES CLONAL GROWTH OF CARCINOMA-CELLS INVITRO
RHODAMINE-123 SELECTIVELY REDUCES CLONAL GROWTH OF CARCINOMA-CELLS INVITRO
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DOI：
10.1126/science.7146897
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发表时间：
1982-01-01
期刊：
影响因子：
56.9
通讯作者：
CHEN, LB
中科院分区：
文献类型：
--
作者：
BERNAL, SD;LAMPIDIS, TJ;CHEN, LB
罗丹明-123，一种阳离子激光染料，显著降低癌的克隆生长[即，小鼠膀胱MB 49细胞]细胞但对非致瘤上皮细胞几乎没有影响[即，正常小鼠膀胱细胞]。罗丹明-123对某些癌的这种选择性抑制作用是不寻常的，因为已知的抗癌药物，如阿糖胞苷和甲氨蝶呤，在体外没有显示出这种选择性。
Rhodamine-123, a cationic laser dye, markedly reduced the clonal growth of carcinoma [i.e., mouse bladder MB49 cells] cells but had little effect on nontumorigenic epithelial cells [i.e., normal mouse bladder cells] in vitro. This selective inhibitory effect of rhodamine-123 on some carcinomas is unusual since known anticancer drugs, such as arabinosyl cytosine and methotrexate, have not been shown to exhibit such selectivity in vitro.