Stories and Challenges of Genome Wide Association Studies in Livestock - A Review.
Stories and Challenges of Genome Wide Association Studies in Livestock - A Review.
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DOI：
10.5713/ajas.14.0715
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发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
Lee SH
中科院分区：
文献类型：
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作者：
Sharma A;Lee JS;Dang CG;Sudrajad P;Kim HC;Yeon SH;Kang HS;Lee SH
毫无疑问，畜牧业是任何国家经济的主要贡献者之一。家畜的经济价值包括肉类、乳制品、纤维、肥料等。了解和鉴定数量性状基因座（QTL）与重要经济性状的关联被认为对畜牧业有重大意义。在过去的二十年里，人们对基因组上与经济重要性状相关的QTL的定位产生了浓厚的兴趣。随着各种密度的单核苷酸多态性芯片的可用性，有可能鉴定基因组上的区域、QTL和基因，以解释相关性及其对所考虑的表型的影响。全基因组关联研究（genome wide association studies，GWAS）自诞生至今取得了显著的进展。在这篇综述中，我们描述了GWAS在各种牲畜物种中的进展和挑战。
Undoubtedly livestock is one of the major contributors to the economy of any country. The economic value of livestock includes meat, dairy products, fiber, fertilizer etc. Understanding and identifying the associations of quantitative trait loci (QTL) with the economically important traits is believed to substantially benefit the livestock industry. The past two decades have seen a flurry of interest in mapping the QTL associated with traits of economic importance on the genome. With the availability of single nucleotide polymorphism chip of various densities it is possible to identify regions, QTL and genes on the genome that explain the association and its effect on the phenotype under consideration. Remarkable advancement has been seen in genome wide association studies (GWAS) since its inception till the present day. In this review we describe the progress and challenges of GWAS in various livestock species.