Distribution of systemically administered ampicillin, benzylpenicillin, and flucloxacillin in excisional wounds in diabetic and normal rats and effects of local topical vasodilator treatment
Distribution of systemically administered ampicillin, benzylpenicillin, and flucloxacillin in excisional wounds in diabetic and normal rats and effects of local topical vasodilator treatment
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DOI：
10.1128/aac.40.7.1703
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发表时间：
1996-07-01
影响因子：
4.9
通讯作者：
Roberts, MS
中科院分区：
文献类型：
--
作者：
Cross, SE;Thompson, MJ;Roberts, MS
本研究评估了链脲佐菌素治疗的糖尿病大鼠作为糖尿病损伤伤口愈合研究模型的适用性。三种抗生素，氨苄青霉素，苄青霉素，氟氯西林，在伤口和邻近组织部位的正常和糖尿病大鼠的膝盖和腿的分布后30分钟，静脉注射一个单团含有50毫克的所有三种抗生素每公斤体重。组织/血浆比显示抗生素组织渗透似乎与蛋白结合相关。然后确定用血管扩张剂（1%溶液）治疗伤口部位以增加局部血流量和抗生素递送至该部位，并且在糖尿病大鼠中，内皮非依赖性硝普钠似乎比内皮依赖性乙酰胆碱更有效。这些结果表明，在接受抗生素治疗感染溃疡的神经病性糖尿病患者的伤口部位同时给予局部血管扩张剂可增加抗生素向伤口组织部位的递送。
The present study assessed the suitability of the streptozotocin-treated diabetic rat as a model for the study of diabetes-impaired wound healing. The distribution of three antibiotics, ampicillin, benzylpenicillin, and flucloxacillin, in wound and adjacent tissue sites on the abdomens and legs of normal and diabetic rats was determined 30 min after intravenous administration of a single bolus containing 50 mg of all three antibiotics per kg of body weight. Tissue/plasma ratios showed that antibiotic tissue penetration appeared to be related to protein binding. The treatment of wound sites with vasodilators (1% solution) to increase local blood flow and antibiotic delivery to the site was then determined and appeared to be more effective with endothelium-independent sodium nitroprusside than with endothelium-dependent acetylcholine in diabetic rats. These results suggest that coadministration of topical vasodilators to wound sites in neuropathic diabetic patients undergoing antibiotic therapy for infected ulcers could increase antibiotic delivery to wound tissue sites.