Results from the IRS-IV randomized trial of hyperfractionated radiotherapy in children with rhabdomyosarcoma - A report from the IRSG
Results from the IRS-IV randomized trial of hyperfractionated radiotherapy in children with rhabdomyosarcoma - A report from the IRSG
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DOI：
10.1016/s0360-3016(01)01709-6
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发表时间：
2001-11-01
影响因子：
7
通讯作者：
Wharam, M
中科院分区：
文献类型：
--
作者：
Donaldson, SS;Meza, J;Wharam, M
目的：评价超分割放射治疗（HFRT）与常规分割放射治疗（CFRT）在儿童组III横纹肌肉瘤（RMS）的结果和毒性。方法和材料：559名儿童被纳入组间横纹肌肉瘤研究IV与G-组III RMS。69例因分组或病理结果不正确而不适合进行分析。在剩余的490例患者中，239例随机接受HFRT（59.4戈伊，54例1.1-戈伊，每日2次），251例接受CFRT（50.4戈伊，28例1.8-戈伊，每日2次）。年龄范围为
Purpose: To evaluate the outcome and toxicity of hyperfractionated radiotherapy (HFRT) vs. conventionally fractionated radiotherapy (CFRT) in children with Group III rhabdomyosarcoma (RMS).Methods and Materials: Five hundred fifty-nine children were enrolled into the Intergroup Rhabdomyosarcoma Study IV with G-roup III RMS. Sixty-nine were ineligible for the analysis because of incorrect group or pathologic findings. Of the 490 remaining, 239 were randomized to HFRT (59.4 Gy in 54 1.1-Gy twice daily fractions) and 251 to CFRT (50.4 Gy in 28 1.8-Gy daily fractions). The age range was