Control of glutamate clearance and synaptic efficacy by glial coverage of neurons
Control of glutamate clearance and synaptic efficacy by glial coverage of neurons
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DOI：
10.1126/science.1059162
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发表时间：
2001-05-04
期刊：
影响因子：
56.9
通讯作者：
Poulain, DA
中科院分区：
文献类型：
--
作者：
Oliet, SHR;Piet, R;Poulain, DA
对大鼠下丘脑视上核兴奋性突触传递的分析表明，谷氨酸清除率以及细胞外空间中谷氨酸浓度和扩散与其神经元的星形胶质细胞覆盖程度相关。谷氨酸清除率的减少，无论是药理学引起的还是与突触附近神经胶质覆盖相对减少有关，都会通过调节突触前代谢型谷氨酸受体影响递质释放，因此，神经元的星形胶质细胞包裹有助于调节中枢神经系统的突触功效。
Analysis of excitatory synaptic transmission in the rat hypothalamic supraoptic nucleus revealed that glutamate clearance and, as a consequence, glutamate concentration and diffusion in the extracellular space, is associated with the degree of astrocytic coverage of its neurons. Reduction in glutamate clearance, whether induced pharmacologically or associated with a relative decrease of glial coverage in the vicinity of synapses, affected transmitter release through modulation of presynaptic metabotropic glutamate receptors, Astrocytic wrapping of neurons, therefore, contributes to the regulation of synaptic efficacy in the central nervous system.