Bone marrow niches for hematopoietic stem cells and immune cells.
Bone marrow niches for hematopoietic stem cells and immune cells.
复制标题
造血干细胞和免疫细胞的骨髓壁ni。
DOI：
10.2174/187152812800392689
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发表时间：
2012-06
期刊：
影响因子：
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通讯作者：
Nagasawa T
中科院分区：
文献类型：
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作者：
Sugiyama T;Nagasawa T
在哺乳动物中，造血干细胞（hsc）产生所有血细胞及其后代，包括免疫细胞，在体内平衡和感染期间受到骨髓中称为生态位的特殊微环境的控制。然而，这些生态位的身份、性质和功能仍不清楚。据报道，造血干细胞与骨表面的成骨细胞接触，成骨细胞作为造血干细胞的壁龛（称为骨内壁龛）。然而，最近的研究表明，只有少数造血干细胞存在于内皮生态位。相反，许多造血干细胞显示与骨髓中的内皮细胞接触。此外，最近的研究表明，原始间充质细胞，包括富含cxcl12的网状（CAR）细胞和表达巢蛋白的细胞，具有向脂肪细胞和成骨细胞分化的能力，可以作为造血干细胞的壁龛。在这里，我们回顾骨髓中造血干细胞控制造血和慢性炎症的候选壁龛。
In mammals, hematopoietic stem cells (HSCs), which give rise to all blood cells and their progenies, including immune cells are controlled by special microenvironments, termed niches in the bone marrow during homeostasis and infection. However, the identity, nature and function of these niches remain unclear. It has been reported that HSCs are in contact with osteoblasts lining the bone surface and osteoblasts act as niches for HSCs (termed endosteal niche). However, recent studies suggest that only a small number of HSCs reside in the endosteal niche. In contrast, many HSCs are shown to be in contact with endothelial cells in the marrow. In addition, recent studies suggest that primitive mesenchymal cells, including CXCL12-abundant reticular (CAR) cells and Nestin-expressing cells, which have the ability to differentiate into adipocytes as well as osteoblasts act as niches for HSCs. Here we review candidate niches for HSCs in the bone marrow controlling hematopoiesis and chronic inflammation.