Pathogenesis and classification of eosinophil disorders: a review of recent developments in the field.
Pathogenesis and classification of eosinophil disorders: a review of recent developments in the field.
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DOI：
10.1586/ehm.11.81
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发表时间：
2012-04
影响因子：
2.8
通讯作者：
Klion AD
中科院分区：
文献类型：
--
作者：
Valent P;Gleich GJ;Reiter A;Roufosse F;Weller PF;Hellmann A;Metzgeroth G;Leiferman KM;Arock M;Sotlar K;Butterfield JH;Cerny-Reiterer S;Mayerhofer M;Vandenberghe P;Haferlach T;Bochner BS;Gotlib J;Horny HP;Simon HU;Klion AD
嗜酸性粒细胞及其产物在各种反应性和肿瘤性疾病的发病机制中起着重要作用。根据基础疾病、分子缺陷和相关细胞因子，可能发生嗜酸性粒细胞增多并可能导致器官损伤。在其他患者中，持续性嗜酸性粒细胞增多症伴有典型的临床表现，但嗜酸性粒细胞增多症的致病作用和影响仍不确定。对于嗜酸性粒细胞介导的器官病理学患者，使用降低嗜酸性粒细胞计数的药物进行早期治疗干预可有效限制或预防不可逆的器官损伤。因此，重要的是要接近嗜酸性粒细胞疾病和相关综合征早期通过使用已建立的标准，进行所有适当的分期调查，并寻找治疗的分子靶点。在这篇文章中，我们回顾了目前的概念，在肿瘤和非肿瘤条件下的嗜酸性粒细胞和嗜酸性粒细胞相关的器官损害的发病机制和演变。此外，我们还讨论了嗜酸性粒细胞疾病和相关综合征的分类，以及各种嗜酸性粒细胞相关疾病的诊断算法和标准治疗。
Eosinophils and their products play an essential role in the pathogenesis of various reactive and neoplastic disorders. Depending on the underlying disease, molecular defect and involved cytokines, hypereosinophilia may develop and may lead to organ damage. In other patients, persistent eosinophilia is accompanied by typical clinical findings, but the causative role and impact of eosinophilia remain uncertain. For patients with eosinophil-mediated organ pathology, early therapeutic intervention with agents reducing eosinophil counts can be effective in limiting or preventing irreversible organ damage. Therefore, it is important to approach eosinophil disorders and related syndromes early by using established criteria, to perform all appropriate staging investigations, and to search for molecular targets of therapy. In this article, we review current concepts in the pathogenesis and evolution of eosinophilia and eosinophil-related organ damage in neoplastic and non-neoplastic conditions. In addition, we discuss classifications of eosinophil disorders and related syndromes as well as diagnostic algorithms and standard treatment for various eosinophil-related disorders.
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DOI：
10.1111/j.1365-2222.2008.03173.x
发表时间：
2009-03
期刊：
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
影响因子：
--
作者：
Bochner BS
通讯作者：
Bochner BS
DOI：
10.1073/pnas.0404438101
发表时间：
2004-10-05
影响因子：
11.1
作者：
Chen, J;DeAngelo, DJ;Gilliland, DG
通讯作者：
Gilliland, DG
影响因子：
14.2
作者：
BOCHNER, BS;SCHLEIMER, RP
通讯作者：
SCHLEIMER, RP
影响因子：
158.5
作者：
Apperley, JF;Gardembas, M;Goldman, JM
通讯作者：
Goldman, JM
影响因子：
11.4
作者：
Burgstaller, S.;Kreil, S.;Cross, N. C. P.
通讯作者：
Cross, N. C. P.