Design of Hydrolytically Degradable Polyethylene Glycol Crosslinkers for Facile Control of Hydrogel Degradation
Design of Hydrolytically Degradable Polyethylene Glycol Crosslinkers for Facile Control of Hydrogel Degradation
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DOI：
10.1002/mabi.202000085
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发表时间：
2020-07-30
影响因子：
4.6
通讯作者：
Zustiak, Silviya P.
中科院分区：
文献类型：
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作者：
Kroger, Stephanie M.;Hill, Lindsay;Zustiak, Silviya P.
水凝胶的降解性可以控制，同时还保持细胞活力或生物分子稳定性，是需要的。可降解聚乙二醇交联剂是水解设计用于水凝胶。降解受交联剂化学结构控制，例如在可降解酯部分附近引入局部疏水性、空间位阻或吸电子部分。使用这些交联剂制备的水凝胶的凝胶化时间为1至22分钟，储能模量为3至10 kPa，筛目尺寸为10至13 nm，降解时间为18 h至16 d。然而，当改变反应条件以实现相似的凝胶化时间时，水凝胶具有相似的初始性质，但保留了宽范围的降解时间。所有交联剂在水凝胶包封或暴露于可降解物和降解产物时都支持高细胞活力。这种控制降解的创新可以帮助实现水凝胶用于药物递送或作为细胞封装和移植基质的潜力。
Hydrogels, whose degradability can be controlled while also preserving cell viability or biomolecule stability, are in demand. Degradable polyethylene glycol crosslinkers are hydrolytically designed for use in hydrogels. Degradation is controlled by crosslinker chemical structure, such as introducing local hydrophobicity, steric hindrance, or electron-withdrawing moieties near a degradable ester moiety. Hydrogels made using these crosslinkers have gelation times from 1 to 22 min, storage moduli from 3 to 10 kPa, mesh sizes from 10 to 13 nm, and degradation times from 18 h to 16 d. However, when reaction conditions are modified to achieve similar gelation time, hydrogels have similar initial properties but preserve the wide range of degradation times. All crosslinkers support high cell viability upon hydrogel encapsulation or exposure to leachables and degradation products. This innovation in controlling degradation can help realize the hydrogels' potential for drug delivery or as matrices for cell encapsulation and transplantation.