Clinical relevance of amphiregulin and VEGF in primary breast cancers
Clinical relevance of amphiregulin and VEGF in primary breast cancers
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DOI：
10.1002/ijc.20312
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发表时间：
2004-09-20
影响因子：
6.4
通讯作者：
Berthois, Y
中科院分区：
文献类型：
--
作者：
Desruisseau, S;Palmari, J;Berthois, Y
乳腺癌新的预后标记物的特征对于提高对高危人群的识别是必要的。在我们的研究中，我们研究了血管内皮生长因子和双调节蛋白(AR)在原发性乳腺癌中的预后意义，并与传统的预后因素进行了比较。对193名患者进行了酶联免疫分析，并对总体人群以及分为结节阴性(N-)和结节阳性(N+)两个亚组的绝经前和绝经后患者进行了单变量和多变量分析。绝经前N+组AR(中位数44.8pg/mg蛋白)与孕激素受体(PgR)呈正相关(P=9.0018)，绝经后/N+组AR与uPA(P=0.020)、血管内皮生长因子(P=0.0053)呈正相关。尽管有这些吸引人的数据，AR的表达对复发或生存结果并不显著。数据显示，在N+人群中，血管内皮生长因子与uPA和PAI-I有很强的相关性。此外，血管内皮生长因子水平高的患者预后较差，N+亚群的风险增加。这些数据被多因素分析证实，组织学分级(HR，10.55，p=0.00 1)和血管内皮生长因子(HR，3.89，p=0.03)是N+人群总体生存的显著预后标志。此外，浸润性导管癌(IDC)uPA(p<；0.000 1)和血管内皮生长因子(p=0.002)的表达均高于小叶内癌。这项回顾性研究强化了血管内皮生长因子在乳腺肿瘤进展中的贬损生物学作用。我们的数据还表明，血管内皮生长因子和uPA可能在IDC的生物学和进展中发挥特殊作用。(C)2004年Wiley-Liss公司
The characterization of novel prognostic markers in breast cancer is necessary to improve the identification of high-risk populations. In our study the prognostic significance of VEGF and amphiregulin (AR) was investigated and compared to conventional prognostic factors in primary breast cancers. The analysis was performed using enzyme-linked immunoassay in a series of 193 patients, and univariate and multivariate analysis were performed in the overall population as well as in pre- and post-menopausail patients subdivided in node-negative (N-) and node-positive (N+) subsets. AR (median, 44.8 pg/m g protein) appeared strongly correlated with progesterone receptors (PgR) (P = 9.0018) in the premeno-: pausal N+ population, and with uPA (p= 0.020) and VEGF (p= 0.0053) in the postmenopausal/N+ patients. Despite these attractive data, AR expression was not significant for recurrence or survival outcome. Data revealed strong correlation between VEGF and uPA, and PAI-I, in the N+ population. Moreover, patients with high VEGF levels displayed poor outcome, with an increased risk The N+ subset. These data were confirmed by multivariate analysis that presented histologic grade (HR, 10.55, p = 0.00 1) and VEGF (HR, 3.89, p = 0.03) as the prominent prognostic markers for overall survival for the N+ population. Furthermore, infiltrating ductal carcinomas (IDC) were shown to express higher levels of both uPA (p < 0.000 1) and VEGF (p = 0.002) than intralobular carcinomas. This retrospective study reinforces the pejorative biological role of VEGF in the progression of breast tumors. Our data also suggest that VEGF and uPA might play particular role in the biology and progression of IDC. (C) 2004 Wiley-Liss, Inc.