Role and Mechanism of PKC-δ for Cardiovascular Disease: Current Status and Perspective.
Role and Mechanism of PKC-δ for Cardiovascular Disease: Current Status and Perspective.
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PKC-δ 在心血管疾病中的作用和机制：现状和展望
DOI：
10.3389/fcvm.2022.816369
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发表时间：
2022
影响因子：
3.6
通讯作者：
Guo M
中科院分区：
文献类型：
--
作者：
Miao LN;Pan D;Shi J;Du JP;Chen PF;Gao J;Yu Y;Shi DZ;Guo M
蛋白激酶C（PKC）是一种具有重要细胞功能的蛋白激酶。PKC-δ是PKC亚家族中的一个新成员，近年来被广泛报道。PKC-δ的活化在心肌缺血/再灌注（IRI）损伤和心肌纤维化中起重要的调节作用，其活性和表达水平可调节动脉粥样硬化、高血压、心肌肥厚和心力衰竭等病理性心血管疾病。本文就PKC-δ的结构与功能、PKC-δ的激活机制及其在心血管疾病中的作用进行综述，为进一步研究PKC-δ在心血管疾病中的作用提供新的思路。
Protein kinase C (PKC) is a protein kinase with important cellular functions. PKC-δ, a member of the novel PKC subfamily, has been well-documented over the years. Activation of PKC-δ plays an important regulatory role in myocardial ischemia/reperfusion (IRI) injury and myocardial fibrosis, and its activity and expression levels can regulate pathological cardiovascular diseases such as atherosclerosis, hypertension, cardiac hypertrophy, and heart failure. This article aims to review the structure and function of PKC-δ, summarize the current research regarding its activation mechanism and its role in cardiovascular disease, and provide novel insight into further research on the role of PKC-δ in cardiovascular diseases.
影响因子：
2.7
作者：
Wojtovich AP;Nadtochiy SM;Urciuoli WR;Smith CO;Grunnet M;Nehrke K;Brookes PS
通讯作者：
Brookes PS