Individualized recording chambers for non-human primate neurophysiology.
Individualized recording chambers for non-human primate neurophysiology.
复制标题
DOI：
10.1016/j.jneumeth.2012.03.014
复制
发表时间：
2012-05-30
影响因子：
3
通讯作者：
Helms Tillery SI
中科院分区：
文献类型：
--
作者：
McAndrew RM;Lingo VanGilder JL;Naufel SN;Helms Tillery SI
虽然非人类灵长类动物的神经记录室可以在商业上购买，但这些通用的记录室并不与动物的头骨轮廓相同。为了密封缝隙，经常在腔室周围贴上牙科丙烯酸(甲基丙烯酸甲酯)的盖子。这种方法有多个缺点。涂抹丙烯酸会延迟手术过程并使手术进一步复杂化，而且在固化过程中过热可能会对骨骼造成损害。手术后，亚克力边缘会引起细菌生长和感染。在这里，我们描述了一种开发符合个人头骨的定制植入物的方法，从而消除了对丙烯酸的需求。这种方法缩短了手术时间，并显著改善了房室边缘的卫生状况。
While neural recording chambers for non-human primates can be purchased commercially, these generic chambers do not contour to the animal’s skull. In order to seal gaps, a cap of dental acrylic (methyl methacrylate) is often applied around the chamber. There are multiple disadvantages associated with this method. Applying acrylic delays and further complicates surgical procedure, and overheating during the curing process can cause damage to the bone. Post-surgery, acrylic margins can give rise to bacterial growth and infection. Here we describe a method to develop custom implants which conform to the individual’s skull, thereby eliminating the need for acrylic. This method shortens surgery time and significantly improves the hygiene of chamber margins.