The Sla2p/HIP1/HIP1R family: similar structure, similar function in endocytosis?
The Sla2p/HIP1/HIP1R family: similar structure, similar function in endocytosis?
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DOI：
10.1042/bst0380187
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发表时间：
2010-02-01
影响因子：
3.9
通讯作者：
Ashery, Uri
中科院分区：
文献类型：
--
作者：
Gottfried, Irit;Ehrlich, Marcelo;Ashery, Uri
亨廷顿蛋白相互作用蛋白1(HIP1)有两个近亲：HIP1R(HIP1相关)和酵母Sla2p。该家族的三个成员都有一个保守的结构域结构，这意味着一个共同的功能。在过去的十年里，许多研究使用了生化、成像、结构和遗传技术的组合来表征这些蛋白质。这些研究为HIP1/HIP1R/Sla2p的结合伙伴、结构和动力学提供了有价值的信息。总体而言，所有这些都表明这三种蛋白质在CME(笼蛋白介导的内吞作用)中发挥了作用，尽管也出现了一些差异。在这篇简短的综述中，我们总结了关于这些蛋白质的作用的最新观点，同时强调了每个家族成员的独特属性。
HIP1 (huntingtin interacting protein 1) has two close relatives: HIP1R (HIP1-related) and yeast Sla2p. All three members of the family have a conserved domain structure, suggesting a common function. Over the past decade, a number of studies have characterized these proteins using a combination of biochemical, imaging, structural and genetic techniques. These studies provide valuable information on binding partners, structure and dynamics of HIP1/HIP1R/Sla2p. in general, all suggest a role in CME (clathrin-mediated endocytosis) for the three proteins, though some differences have emerged. In this mini-review we summarize the current views on the roles of these proteins, while emphasizing the unique attributes of each family member.