Teicoplanin, antibiotics from Actinoplanes teichomyceticus nov. sp. V. Aromatic constituents.
Teicoplanin, antibiotics from Actinoplanes teichomyceticus nov. sp. V. Aromatic constituents.
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替考拉宁，来自 Actinoplanes teichomyceticus nov 的抗生素。
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
G. Gallo
中科院分区：
文献类型：
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作者：
C. Coronelli;M. Bardone;A. Depaoli;P. Ferrari;G. Tuan;G. Gallo
对替考拉宁进行氧化和水解降解反应，以表征分子的芳香部分并将其与糖肽抗生素类的其他成员联系起来。鉴定出替考拉宁氧化和水解后得到的七个芳环，分别为三苯醚、二苯醚和二苯基部分。它们以芳香族氨基酸的形式存在于替考拉宁中，并构成分子的肽部分。二苯醚和二苯基部分在氧化后以酯的形式分离出来，在酸水解后以α-氨基酸的形式分离出来，清楚地表明了替考拉宁中相应氨基酸的性质。仅以酯的形式分离出的三苯醚部分允许假设相应的氨基酸与其他糖肽抗生素的氨基酸相同。
Oxidative and hydrolytic degradation reactions were carried out on teicoplanin in order to characterize the aromatic portion of the molecule and relate it to the other members of the class of glycopeptide antibiotics. Seven aromatic rings, obtained as triphenyl ether, diphenyl ether, and diphenyl moieties after oxidation nd hydrolysis of teicoplanin, were identified. They are present in teicoplanin as aromatic amino acids and constitute the peptidic part of the molecule. The diphenyl ether and diphenyl moieties, which were isolated both as esters after oxidation and as alpha-amino acids after acid hydrolysis clearly indicate the nature of the corresponding amino acids in teicoplanin. The triphenyl ether moiety, which was isolated only as ester, allows the hypothesis that the corresponding amino acids are the same as those of the other glycopeptide antibiotics.