Eczema phenotypes and IgE component sensitization in adolescents: A population-based birth cohort
Eczema phenotypes and IgE component sensitization in adolescents: A population-based birth cohort
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青少年湿疹表型和 IgE 成分致敏：基于人群的出生队列
DOI：
10.1016/j.alit.2022.05.012
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发表时间：
2023
影响因子：
6.8
通讯作者：
Ohya Yukihiro
中科院分区：
文献类型：
--
作者：
Kiguchi Tomoyuki;Yamamoto-Hanada Kiwako;Saito-Abe Mayako;Fukuie Tatsuki;Ohya Yukihiro
背景：湿疹患者多为免疫球蛋白（IG）E致敏。虽然特应性皮炎（AD）表型已被认可，IgE过敏模式的基础上AD表型尚未得到很好的说明。我们的目的是调查湿疹表型如何影响IgE成分sensitivity patterns.Methods：这项出生队列研究调查了东京儿童健康，疾病和发展研究（T-儿童研究）的一般人群，直到儿童达到13岁。使用国际儿童哮喘和过敏研究（ISAAC）问卷评估过敏。使用多重阵列ImmunoCAP ISAC测量变应原组分特异性IgE抗体滴度。持续湿疹表型，直到青春期与过敏性行军症状，如喘息和花粉热，口腔过敏症状，和IgE成分致敏的空气传播的（日本雪松，屋尘螨，蒂莫西，猫和狗）和交叉反应性过敏原（Bet v 1家族）相比，早期缓解和迟发性湿疹。另一方面，迟发性湿疹与过敏症状和IgE致敏性没有任何强相关性。结论：早发性湿疹与迟发性湿疹有密切关系，迟发性湿疹与过敏性湿疹的表型不同。以IgE致敏为特征的早发性湿疹可能是外源性湿疹，而与IgE致敏无关的晚发性湿疹可能是内源性湿疹。花粉-食物过敏综合征是过敏性疾病的特征之一。
Background: Eczema patients are commonly immunoglobulin (Ig) E polysensitized. Although atopic dermatitis (AD) phenotypes have been recognized, IgE sensitization patterns based on AD phenotypes have not been well illustrated. We aimed to investigate how eczema phenotypes impact IgE component sensitization patterns.Methods: This birth cohort study investigated a general population in the Tokyo Children's Health, Illness, and Development Study (T-Child Study) until children reached the age of 13 years. Eczema was assessed using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Allergen component specific IgE antibody titers were measured using a multiplex array ImmunoCAP ISAC.Results: Persistent eczema phenotype until adolescence was strongly associated with allergic march symptoms, such as wheezing and hay fever, and oral allergy symptoms, and IgE component sensitizations of airborne (Japanese cedar, house dust mite, Timothy, cat, and dog) and cross-reactive allergens (Bet v 1 family) compared to early-remission and late-onset eczema. On the other hand, late-onset eczema did not show any strong associations with allergic symptoms and IgE sensitization. Adolescents with persistent eczema have high comorbidity of symptoms of pollen-food allergy syndrome.Conclusions: Early-onset eczema is deeply connected with the later allergic march, and late-onset eczema differs from the phenotype of allergic march. Early-onset eczema characterizing IgE sensitization was likely to be an extrinsic type, and late-onset eczema, which was not related to IgE sensitization, was likely an intrinsic type. Pollen-Food Allergy Syndrome is one of the allergic features in allergic march.