A clinical trial to validate event-related potential markers ofAlzheimer'sdisease in outpatient settings.
A clinical trial to validate event-related potential markers ofAlzheimer'sdisease in outpatient settings.
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DOI：
10.1016/j.dadm.2015.08.004
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发表时间：
2015-12-01
期刊：
影响因子：
--
通讯作者：
Fadem, Kalford C
中科院分区：
文献类型：
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作者：
Cecchi, Marco;Moore, Dennis K;Fadem, Kalford C
简介：我们调查了在门诊收集并使用标准化方法进行分析的事件相关电位 (ERP) 是否可以提供与早期阿尔茨海默病 (AD) 相关的认知缺陷的灵敏且可靠的测量。方法：在 7 个临床研究中心总共招募了 103 名可能患有轻度 AD 的受试者和 101 名健康对照。使用奇怪的听觉 ERP 范式对受试者进行测试。结果：患有轻度 AD 的受试者表现出与注意力、工作记忆和执行功能相关的 ERP 特征的振幅较低和延迟增加。这些受试者在与 ERP 测试相关的目标检测任务中的准确性也有所下降，反应时间也更长。讨论：ERP 数据分析显示，轻度 AD 受试者发生了显着变化，这与该人群中发现的认知缺陷一致。使用集成的硬件/软件系统进行数据采集和自动数据分析方法使得 ERP 测试的管理在门诊环境中变得实用。
INTRODUCTION: We investigated whether event-related potentials (ERP) collected in outpatient settings and analyzed with standardized methods can provide a sensitive and reliable measure of the cognitive deficits associated with early Alzheimer's disease (AD).METHODS: A total of 103 subjects with probable mild AD and 101 healthy controls were recruited at seven clinical study sites. Subjects were tested using an auditory oddball ERP paradigm.RESULTS: Subjects with mild AD showed lower amplitude and increased latency for ERP features associated with attention, working memory, and executive function. These subjects also had decreased accuracy and longer reaction time in the target detection task associated with the ERP test.DISCUSSION: Analysis of ERP data showed significant changes in subjects with mild AD that are consistent with the cognitive deficits found in this population. The use of an integrated hardware/software system for data acquisition and automated data analysis methods make administration of ERP tests practical in outpatient settings.