Case-crossover studies of occupational trauma: methodological caveats.
Case-crossover studies of occupational trauma: methodological caveats.
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DOI：
10.1136/ip.7.suppl_1.i38
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发表时间：
2001-09-01
期刊：
影响因子：
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通讯作者：
Mittleman, M A
中科院分区：
文献类型：
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作者：
Sorock, G S;Lombardi, D A;Mittleman, M A
注意事项：病例交叉研究设计旨在检查心肌梗死发作的触发因素。本文旨在探讨选定的方法学问题时，应用的情况下，交叉方法的研究工作环境中的创伤injuries.METHODS：研究人员被称为是工作在职业的情况下，交叉研究被邀请出席在2000年10月举行的全国职业伤害研究研讨会的研讨会。来自正在进行的研究的数据被用来说明职业伤害病例交叉研究中涉及的各种方法学问题。为了利用病例交叉设计，调查人员必须明确定义工人处于受伤风险的时间，特定瞬时暴露可能导致伤害的时间段，并仔细选择估计预期频率的控制时间段暴露。其他关注的问题是随着时间的推移不断变化的工作任务，随着时间的推移和信息偏差的相关暴露。结论和未来的研究需求：需要更多的职业伤害的病例交叉研究，比较多项研究的结果。无论是在实验室还是在现场环境中，都应该对相对于伤害发生的瞬时暴露时间进行验证。其他流行病学研究（病例对照或队列研究）中的巢式病例交叉设计可以检查职业伤害的瞬时和固定危险因素，应该尝试。
OBJECTIVES: The case-crossover study design was developed to examine triggers for the onset of myocardial infarction. This paper seeks to examine selected methodological issues when applying the case-crossover method to the study of traumatic injuries in the work environment.METHODS: Researchers known to be working on occupational case-crossover studies were invited to present at a workshop held at the National Occupational Injury Research Symposium in October 2000. Data from ongoing studies were used to illustrate various methodological issues involved in case-crossover studies of occupational injury.KEY FINDINGS AND ISSUES IDENTIFIED: To utilize the case-crossover design, investigators must clearly define the time during which a worker is at risk of injury, the period of time during which a particular transient exposure could cause an injury and carefully select control time periods that estimate the expected frequency of exposure. Other issues of concern are changing work tasks over time, correlated exposures over time and information bias.CONCLUSIONS AND FUTURE RESEARCH NEEDS: More case-crossover studies of occupational injury are needed to compare results from multiple studies. The validation of the timing of transient exposures relative to injury onset, whether done in a laboratory or field setting, should be conducted. Nested case-crossover designs in other epidemiological studies (case-control or cohort) can examine both transient and fixed risk factors for occupational injury, and should be attempted.