EMT is the dominant program in human colon cancer.
EMT is the dominant program in human colon cancer.
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EMT是人类结肠癌的主要计划。
DOI：
10.1186/1755-8794-4-9
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发表时间：
2011-01-20
影响因子：
2.7
通讯作者：
Yeatman TJ
中科院分区：
文献类型：
--
作者：
Loboda A;Nebozhyn MV;Watters JW;Buser CA;Shaw PM;Huang PS;Van't Veer L;Tollenaar RA;Jackson DB;Agrawal D;Dai H;Yeatman TJ
Colon cancer has been classically described by clinicopathologic features that permit the prediction of outcome only after surgical resection and staging. We performed an unsupervised analysis of microarray data from 326 colon cancers to identify the first principal component (PC1) of the most variable set of genes. PC1 deciphered two primary, intrinsic molecular subtypes of colon cancer that predicted disease progression and recurrence. Here we report that the most dominant pattern of intrinsic gene expression in colon cancer (PC1) was tightly correlated (Pearson R = 0.92, P < 10-135) with the EMT signature-- both in gene identity and directionality. In a global micro-RNA screen, we further identified the most anti-correlated microRNA with PC1 as MiR200, known to regulate EMT. These data demonstrate that the biology underpinning the native, molecular classification of human colon cancer--previously thought to be highly heterogeneous-- was clarified through the lens of comprehensive transcriptome analysis.
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影响因子：
50.3
作者：
Singh A;Greninger P;Rhodes D;Koopman L;Violette S;Bardeesy N;Settleman J
通讯作者：
Settleman J
DOI：
10.1158/1055-9965.epi-08-1002
发表时间：
2009-02
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Rosser CJ;Liu L;Sun Y;Villicana P;McCullers M;Porvasnik S;Young PR;Parker AS;Goodison S
通讯作者：
Goodison S
影响因子：
8.8
作者：
通讯作者：
--
影响因子：
4
作者：
Ganepola, Ganepola A. P.;Mazziotta, Robert M.;Mariadason, John M.
通讯作者：
Mariadason, John M.
影响因子：
64.8
作者：
Bild, AH;Yao, G;Nevins, JR
通讯作者：
Nevins, JR