Dermoscopy Pattern, Histopathology and Immunophenotype of Primary Cutaneous B-Cell Lymphoma Presenting as a Solitary Skin Nodule
Dermoscopy Pattern, Histopathology and Immunophenotype of Primary Cutaneous B-Cell Lymphoma Presenting as a Solitary Skin Nodule
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DOI：
10.1159/000442251
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发表时间：
2016-01-01
期刊：
影响因子：
3.4
通讯作者：
Staibano, Stefania
中科院分区：
文献类型：
--
作者：
Mascolo, Massimo;Piccolo, Vincenzo;Staibano, Stefania
重要性：迄今为止，尚未描述用于诊断原发性皮肤 B 细胞淋巴瘤 (PCBCL) 的皮肤镜特征。该工具可能有助于皮肤单个红斑结节的临床鉴别诊断。观察结果：回顾性检索 10 例临床表现为孤立性红色/粉红色结节的 PCBCL。收集患者数据以及每个病变的皮肤镜和组织病理学特征。大多数病变（9/10）显示具有鲑鱼色背景/区域的白色圆圈（6个病变）、鳞片（7个病变）、树枝状血管（5个病变）或多形性血管图案（2个病变）。组织学显示 6 个病灶为皮肤边缘区淋巴瘤，2 个病灶为滤泡中心淋巴瘤，2 个病灶为弥漫性大 B 细胞淋巴瘤。结论和相关性：尽管皮肤活检仍然是强制性的，但皮肤镜检查可能有助于提高 PCBCL 的临床识别率。 (C) 2015 S. Karger AG，巴塞尔
Importance: To date, no dermoscopic features have been described for the diagnosis of primary cutaneous B-cell lymphoma (PCBCL). This tool might be helpful for the clinical differential diagnosis in the context of single erythematous nodules of the skin. Observations: Ten cases of PCBCL, presenting clinically as solitary red/pinkish nodules, were retrospectively retrieved. Patient data were collected along with dermoscopic and histopathological features of each lesion. Most lesions (9/10) showed white circles with a salmon-colored background/area (6 lesions), scales (7 lesions), arborizing vessels (5 lesions) or a polymorphous vascular pattern (2 lesions). Histology revealed a cutaneous marginal zone lymphoma in 6 lesions, a follicle center lymphoma in 2 lesions and a diffuse large B-cell lymphoma in 2 lesions. Conclusions and Relevance: Dermoscopic examination may be helpful for improving the clinical recognition of PCBCL although skin biopsy remains mandatory. (C) 2015 S. Karger AG, Basel