The neuron specific enolase (NSE) ratio offers benefits over absolute value thresholds in post-cardiac arrest coma prognosis.
The neuron specific enolase (NSE) ratio offers benefits over absolute value thresholds in post-cardiac arrest coma prognosis.
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DOI：
10.1016/j.jocn.2018.08.020
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发表时间：
2018-11
期刊：
影响因子：
--
通讯作者：
Hirsch KG
中科院分区：
文献类型：
--
作者：
Chung-Esaki HM;Mui G;Mlynash M;Eyngorn I;Catabay K;Hirsch KG
Serum neuron-specific enolase (NSE) levels have been shown to correlate with neurologic outcome in comatose survivors of cardiac arrest but use of absolute NSE thresholds is limited. This study describes and evaluates a novel approach to analyzing NSE, the NSE ratio, and evaluates the prognostic utility of NSE absolute value thresholds and trends over time. 100 consecutive adult comatose cardiac arrest survivors were prospectively enrolled. NSE levels were assessed at 24, 48, and 72 hours post-arrest. Primary outcome was the Glasgow Outcome Score (GOS) at 6 months post-arrest; good outcome was defined as GOS 3-5. Absolute and relative NSE values (i.e. the NSE ratio), peak values, and the trend in NSE over 72 hours were analyzed. 98 patients were included. 42 (43%) had a good outcome. Five good outcome patients had peak NSE >33 μg/L (34.9 – 46.4 μg/L), NSE trends between 24 and 48 hours differed between outcome groups (decrease by 3.0 μg/L (0.9–7.0 μg/L) vs. increase by 13.4 μg/L (−3.7 – 69.4 μg/L), good vs. poor, p=0.004). The 48:24 hour NSE ratio differed between the good and poor outcome groups (0.8 (0.6–0.9) vs. 1.4 (0.8–2.5), p=0.001), and a 48:24 hour ratio of ≥1.7 was 100% specific for poor outcome. The NSE ratio is a unique method to quantify NSE changes over time. Values greater than 1.0 indicate increasing NSE and may be reflective of ongoing neuronal injury. The NSE ratio obviates the need for an absolute value cut-off.
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DOI：
10.1186/cc5046
发表时间：
2006
期刊：
Critical care (London, England)
影响因子：
--
作者：
Rech TH;Vieira SR;Nagel F;Brauner JS;Scalco R
通讯作者：
Scalco R
影响因子：
3.5
作者：
Samaniego, Edgar A.;Mlynash, Michael;Caulfield, Anna Finley;Eyngorn, Irina;Wijman, Christine A. C.
通讯作者：
Wijman, Christine A. C.
影响因子：
6.5
作者：
Pfeifer, R;Börner, A;Figulla, HR
通讯作者：
Figulla, HR
影响因子：
158.5
作者：
Nielsen, Niklas;Wettersley, Jorn;Friberg, Hans
通讯作者：
Friberg, Hans
影响因子：
8.8
作者：
Tong, Julia T.;Eyngorn, Irina;Hirsch, Karen G.
通讯作者：
Hirsch, Karen G.