Dengue: a growing threat requiring vaccine development for disease prevention.
Dengue: a growing threat requiring vaccine development for disease prevention.
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DOI：
10.1080/20477724.2018.1514136
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发表时间：
2018-09
影响因子：
3.4
通讯作者：
Despres P
中科院分区：
文献类型：
--
作者：
Bos S;Gadea G;Despres P
登革热是人类中最常见的蚊媒病毒感染疾病。据估计，全球至少有一半人口面临感染风险，每年约有3.9亿人感染。在过去几年中，登革热的负担持续增加，主要影响发展中国家。观察到登革热流行病学发生了令人担忧的变化，突出表现为从热带地区向亚热带地区以及从城市向农村地区扩散。还注意到四种血清型混合感染的情况有所增加，感染目标人群从儿童转向成人。面对这些全球变化，当局将必须加强预防措施并调整医疗保健管理。迫切需要新的预防策略来预防严重形式的登革热疾病。由于缺乏有效的特异性抗病毒疗法，疫苗研发成为一项社会经济挑战。在这篇综述中，我们对登革热的全球趋势以及正在研发的不同疫苗策略进行了更新。我们将特别关注登革热传播的最新信息以及新上市的四价登革热疫苗登革热疫苗（Dengvaxia®）的保护效力，以及临床研发中最先进的候选疫苗。
Dengue disease is the most prevalent mosquito-borne viral infection in humans. At least one half of the global population is estimated at risk of infection and an estimated 390 million people are infected each year. Over the past few years, dengue burden continued to increase, mainly impacting developing countries. Alarming changes in dengue epidemiology were observed highlighting a spread from tropical to subtropical regions as well as urban to rural areas. An increase in the co-infections with the four serotypes has also been noticed, involving a shift in the targeted population from pediatric to adult. Facing these global changes, authorities will have to reinforce preventive actions and adapt healthcare management. New prophylactic strategies are urgently needed to prevent severe forms of dengue disease. The lack of specific antiviral therapies available turns vaccine development into a socio-economic challenge. In this review, we propose an update on the dengue global trends and different vaccine strategies in development. A particular attention will be paid to up-to-date information on dengue transmission and the protective efficacy of newly commercialized tetravalent dengue vaccine Dengvaxia®, as well as the most advanced candidate vaccines in clinical development.
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影响因子：
5.1
作者：
Gottschamel, Johanna;Loessl, Andreas;Clarke, Jihong Liu
通讯作者：
Clarke, Jihong Liu
影响因子：
5.4
作者：
Butrapet, S;Huang, CYH;Kinney, RM
通讯作者：
Kinney, RM
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7.3
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影响因子：
6.4
作者：
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通讯作者：
Partidos, Charalambos D.
影响因子：
14.2
作者：
Arredondo-Garcia, J. L.;Hadinegoro, S. R.;Zambrano, B.
通讯作者：
Zambrano, B.