Synthesis of cyclic 1,3-diols as scaffolds for spatially directed libraries.
Synthesis of cyclic 1,3-diols as scaffolds for spatially directed libraries.
复制标题
合成环状 1,3-二醇作为空间定向文库的支架。
DOI：
10.1039/c6ob00598e
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发表时间：
2016
影响因子：
3.2
通讯作者：
Aubé,Jeffrey
中科院分区：
文献类型：
--
作者：
Singh,Gurpreet;Aubé,Jeffrey
A useful design element in small molecule libraries is spatial diversity, in which binding moieties are systematically directed toward different regions of three-dimensional space. One way of achieving this is through the use of conformationally diverse scaffolds onto which various binding moieties can be placed. Such scaffolds can represent synthetic challenges of their own. In this paper, we describe a new route to chiral, cyclic 1,3-diol building blocks that features silylated dithianes as relay linchpins. These diols are subsequently used for the construction of a 24-compound pilot library bearing two amino acid residues.
