Gabexate mesilate suppresses influenza pneumonia in mice through inhibition of cytokines
Gabexate mesilate suppresses influenza pneumonia in mice through inhibition of cytokines
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DOI：
10.1177/147323000803600215
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发表时间：
2008-03-01
影响因子：
1.6
通讯作者：
Kohno, S.
中科院分区：
文献类型：
--
作者：
Kosai, K.;Seki, M.;Kohno, S.
甲磺酸加贝酯是一种合成的蛋白酶抑制剂，对急性胰腺炎有效。通过检测小鼠肺部炎症细胞因子和趋化因子的变化，探讨甲磺酸加贝酯对小鼠流感肺炎的治疗作用。与感染、未治疗的小鼠相比，接受治疗的小鼠肺部的病理变化非常轻微。与未治疗的小鼠相比，接受治疗的小鼠肺内白介素6和巨噬细胞炎性蛋白-2的水平降低，尽管肺部的病毒滴度相似。治疗组和未治疗组的生存条件相似。提示甲磺酸加贝酯对流感肺炎有良好的治疗作用，其机制可能与调节炎性细胞因子/趋化因子反应有关。
Gabexate mesilate is a synthetic protease inhibitor that is effective for acute pancreatitis. The effect of gabexate mesilate in influenza pneumonia in mice was investigated by examining the changes in pulmonary inflammatory cytokines and chemokines. Pathological changes in the lungs of treated mice were extremely mild, compared with changes in infected, untreated mice. Intrapulmonary levels of interleukin-6 and macrophage inflammatory protein-2 decreased in treated mice compared with untreated mice, despite similar viral titres in the lungs. Survival terms for treated and untreated groups were similar. These data indicate that gabexate mesilate has beneficial effects on influenza pneumonia, which may be due to the modulation of inflammatory cytokine/chemokine responses.