Urinary exosomal expression of activator of G protein signaling 3 in polycystic kidney disease.
Urinary exosomal expression of activator of G protein signaling 3 in polycystic kidney disease.
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DOI：
10.1186/s13104-018-3467-6
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发表时间：
2018-06-07
影响因子：
1.8
通讯作者：
Park, Frank
中科院分区：
文献类型：
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作者：
Keri, Krishna C;Regner, Kevin R;Park, Frank
目的：PKD是一种以肾脏和肝脏上皮细胞异常增殖为特征的遗传性疾病。尿外泌体先前已被检查为可用于诊断和监测PKD进展的独特蛋白质的来源。我们小组先前的研究表明，AGS 3是一种受体非依赖性调节剂G蛋白，在包括PKD在内的肾损伤期间在RTECs中显著上调。在这项研究中，我们的目标是确定AGS 3是否可以测量外泌体使用动物和人类PKD.RESULTS：在我们的研究中，尿外泌体分离自PCK大鼠和对照Sprague-Dawley（SD）大鼠。AGS 3表达显著增加（P
OBJECTIVE: PKD is a genetic disease that is characterized by abnormally proliferative epithelial cells in the kidney and liver. Urinary exosomes have been previously examined as a source of unique proteins that may be used to diagnose and monitor the progression of PKD. Previous studies by our group have shown that AGS3, which is a receptor-independent regulator G-proteins, was markedly upregulated in RTECs during kidney injury including PKD. In this study, our goal was to determine whether AGS3 could be measured in exosomes using animals and humans with PKD.RESULTS: In our study, urinary exosomes were isolated from PCK rats and the control Sprague-Dawley (SD) rats. AGS3 expression was significantly increased (P