A functional magnetic resonance Imaging study of left hemisphere language dominance in children
A functional magnetic resonance Imaging study of left hemisphere language dominance in children
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DOI：
10.1001/archneur.59.7.1168
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发表时间：
2002-07-01
影响因子：
--
通讯作者：
Gaillard, WD
中科院分区：
文献类型：
--
作者：
Balsamo, LM;Xu, B;Gaillard, WD
背景：功能磁共振成像是评估儿童人群中语言优势的一种非侵入性方法。目的：确定健康儿童接受性语言偏侧化的模式。设计：我们使用功能磁共振成像评估了11名儿童(7名女孩，4名男孩；平均年龄8.5岁)的听觉语言任务。参与者轮流休息，听有声呈现的名词描述符，默默地说出描述的对象。对先验确定的兴趣区计算不对称指数([Left-Right)/(Left+Right)]。结果：双侧激活较强，左侧颞上回和中回激活较大。其他激活的区域包括楔状回、左侧颞下回、前额叶、左侧梭形回和舌回。单次扫描的感兴趣区分析显示，左额叶有额外的激活。不对称指数显示额下回、额中回和WerNicke区的左侧偏侧性较强。与成人一样，接受性语言的左半球偏侧化在8岁时出现。
Background: Functional magnetic resonance imaging is a noninvasive method of assessing language dominance in a pediatric population.Objective: To determine the pattern of receptive language lateralization in healthy children.Design: We used functional magnetic resonance imaging to assess an auditory language task in 11 children (7 girls, 4 boys; mean age, 8.5 years). Participants alternately rested and listened to descriptors of nouns presented auditorily, naming the object described silently. Asymmetry indices ([left - right)/(left + right)]) were calculated for a priori-determined regions of interest.Results: The results showed strong activation bilaterally, with greater activation on the left in the superior and middle temporal gyri. Other areas of activation included the cuneus, the left inferior temporal gyrus, the prefrontal area, and the left fusiform and lingual gyri. Regions of interest analysis of individual scans showed additional activation in the left frontal lobe. Asymmetry indices showed strong left lateralization of the inferior frontal gyrus, middle frontal gyrus, and the Wernicke region.Conclusions: Hemispheric lateralization was clearly demonstrated in 8 children. As in adults, left hemisphere lateralization of receptive language is present at age 8 years.