Nicotine Inhibition of the Metabolism of 3,4-Benzopyrene, a Carcinogen in Tobacco Smoke
Nicotine Inhibition of the Metabolism of 3,4-Benzopyrene, a Carcinogen in Tobacco Smoke
复制标题
尼古丁对烟草烟雾中致癌物质3,4-苯并芘代谢的抑制作用
作者：
R. P. Weber;J. Coon;A. Triolo
A decreased rate of biliary excretion of radioactive metabolites of 3,4-benzopyrene was observed in rats given a single dose of nicotine. Prior treatment of rats with nicotine decreased benzopyrene hydroxylase activity in homogenates of liver, lung, and small intestine. The addition of nicotine to incubated tissues also decreased benzopyrene hydroxylase activity. These findings show that nicotine inhibits the metabolism of 3,4-benzopyrene in vivo and in vitro.
