C28 Terpenoids from Lamiaceous Plant Perovskia scrophulariifolia: Their Structures and Anti-neuroinflammatory Activity
C28 Terpenoids from Lamiaceous Plant Perovskia scrophulariifolia: Their Structures and Anti-neuroinflammatory Activity
复制标题
唇形科植物玄参中的 C28 萜类化合物：其结构和抗神经炎症活性
DOI：
10.1021/acs.orglett.0c02855
复制
发表时间：
2020
期刊：
影响因子：
5.2
通讯作者：
Kashiwada Yoshiki
中科院分区：
文献类型：
--
作者：
Tanaka Naonobu;Niwa Kanji;Kajihara Seita;Tsuji Daisuke;Itoh Kohji;Mamadalieva Nilufar Z.;Kashiwada Yoshiki
从乌兹别克药用植物Perovskia scrophulariifolia（唇形科）的地上部分分离得到结构独特的C28萜类化合物，即perovsfolins A（1）和B（2）。它们的化学结构包括一个前所未有的6/8/6/6/6五环碳骨架与C6-C3酯部分的基础上，通过光谱分析，密度泛函理论计算以及化学证据的辅助下，被阐明。Perovsfolin B（2）具有抗神经炎活性。
Structurally unique C28terpenoids, perovsfolins A (1) and B (2), were isolated from the aerial parts of an Uzbek medicinal plant,Perovskia scrophulariifolia(Lamiaceae). Their chemical structures including an unprecedented 6/8/6/6/6 pentacyclic carbon skeleton with a C6–C3ester moiety were elucidated on the basis of spectroscopic analyses aided by density functional theory calculations as well as chemical evidence. Perovsfolin B (2) exhibited an anti-neuroinflammatory activity.