CSF Flow Dynamics at the Craniovertebral Junction Studied with an Idealized Model of the Subarachnoid Space and Computational Flow Analysis
CSF Flow Dynamics at the Craniovertebral Junction Studied with an Idealized Model of the Subarachnoid Space and Computational Flow Analysis
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DOI：
10.3174/ajnr.a1766
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发表时间：
2010-01-01
影响因子：
3.5
通讯作者：
Langtangen, H. P.
中科院分区：
文献类型：
--
作者：
Linge, S. O.;Haughton, V.;Langtangen, H. P.
背景与目的：脑脊液（CSF）流动如何随蛛网膜下腔解剖结构而变化尚未得到充分研究。本研究的目的是建立一个理想化的蛛网膜下腔三维计算模型，然后利用该模型研究解剖变异或脑脊液压力和流速的详细时空效应。
材料与方法：我们使用计算机辅助设计程序创建了一个几何模型。该模型包含一个用于脑和脊髓轴的中心结构以及一个用于蛛网膜下腔周边边界的外围结构。调整模型尺寸以捕捉正常人颅后窝和颈椎解剖结构的主要特征。将脑脊液流动模拟为具有正弦流动模式的水。使用计算流体动力学（CFD）软件计算头向尾和尾向头流动过程中的流速和压力。将模拟流动与已发表的健康人受试者脑脊液流动的相位对比磁共振成像测量结果进行比较。
结果：该模型包含颅后窝和椎管的几何特征。流速随周期中的时间和空间位置而变化。流速的空间变化与健康人受试者相似。雷诺数适中，显示为层流状态。在头向尾和尾向头流动过程中，压力沿模型长轴均匀变化。
结论：在对人类蛛网膜下腔的理想化几何近似中，可以使用数学模型对脑脊液流速和压力进行时空细节研究。
BACKGROUND AND PURPOSE: How CSF flow varies with the anatomy of the subarachnoid space has not been sufficiently well studied. The goal of this study was to develop an idealized 3D computational model of the subarachnoid space and then to use this model to study the detailed spatiotemporal effects of anatomic variations or CSF pressures and velocities,MATERIALS AND METHODS: We created a geometric model with a computer-assisted design program. The model contained a central structure for the brain and spinal cord axis and a second surrounding structure for the peripheral borders of the subarachnoid space. Model dimensions were adjusted to capture the main characteristics of the normal human posterior fossa and cervical spinal anatomy. CSF flow was modeled as water with a sinusoidal flow pattern in time. Velocities and pressures during craniocaudal and caudocranial flow were calculated with computational fluid dynamics (CFD) software. Simulated flow was compared with published phase-contrast MR imaging measurements of CSF flow in healthy human subjects.RESULTS: The model contained geometric characteristics of the posterior fossa and spinal canal, Flow velocities varied with the time in the cycle and location in space. Flow velocities had spatial variations that resembled those in healthy human subjects. Reynolds numbers were moderate, showing a laminar flow regime. Pressure varied uniformly along the long axis of the model during craniocaudal and caudocranial flow.CONCLUSIONS: In an idealized geometric approximation of the human subarachnoid space, CSF velocities and pressures can be studied in spatiotemporal detail with mathematic models.