The scales and tales of myelination: using zebrafish and mouse to study myelinating glia.
The scales and tales of myelination: using zebrafish and mouse to study myelinating glia.
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DOI：
10.1016/j.brainres.2015.10.011
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发表时间：
2016-06-15
期刊：
影响因子：
2.9
通讯作者：
Monk KR
中科院分区：
文献类型：
--
作者：
Ackerman SD;Monk KR
髓磷脂是一种富含脂质的鞘，可隔离轴突以促进动作电位的快速传导，是有颌脊椎动物谱系的进化创新。旨在理解髓鞘形成的分子机制的研究工作主要集中在啮齿动物模型上；然而，随着斑马鱼模型系统在20世纪后期的出现，使用这种遗传上易于处理，但更简单的脊椎动物来研究髓鞘形成的研究稳步增加。本文比较了斑马鱼和小鼠的髓鞘胶质细胞在发育和再生过程中的生物学特性，并列举了使用每种模型研究髓鞘形成的优缺点。
Myelin, the lipid-rich sheath that insulates axons to facilitate rapid conduction of action potentials, is an evolutionary innovation of the jawed-vertebrate lineage. Research efforts aimed at understanding the molecular mechanisms governing myelination have primarily focused on rodent models; however, with the advent of the zebrafish model system in the late twentieth century, the use of this genetically tractable, yet simpler vertebrate for studying myelination has steadily increased. In this review, we compare myelinating glial cell biology during development and regeneration in zebrafish and mouse and enumerate the advantages and disadvantages of using each model to study myelination.