EFFECT OF VARYING THE DURATION OF PRETEST CAGE HABITUATION ON OXYTOCIN INDUCTION OF SHORT-LATENCY MATERNAL-BEHAVIOR
EFFECT OF VARYING THE DURATION OF PRETEST CAGE HABITUATION ON OXYTOCIN INDUCTION OF SHORT-LATENCY MATERNAL-BEHAVIOR
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DOI：
10.1016/0031-9384(86)90396-3
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发表时间：
1986-01-01
影响因子：
2.9
通讯作者：
PFAFF, DW
中科院分区：
文献类型：
--
作者：
FAHRBACH, SE;MORRELL, JI;PFAFF, DW
先前有报道称，脑室注射催产素可以诱导雌性去卵巢处女大鼠的短潜伏期母体行为(不到一小时需要与寄养幼鼠接触)。脑室注射催产素对母体行为潜伏期的影响的测试包括在注射催产素前一到两小时将动物从家里的笼子转移到更大的测试笼子。通过改变测试前笼子习服的持续时间，评估了这一测试特征对多肽诱导的短潜伏期母体行为的重要性。比较卵巢切除、雌激素刺激的Zivic-Miller SD大鼠在注射催产素或生理盐水前1周、2小时或0小时的反应。研究发现，只有给予两小时预试笼养习服的大鼠对脑室注射催产素治疗的反应具有短潜伏期的母性行为。关于其他研究人员未能用催产素诱导短潜伏期母体行为的这一结果进行了讨论。考虑了环境新颖度与催产素诱导的行为相互作用的可能的神经内分泌机制。
Intracerebroventricular (ICV) infusion of the peptide hormone oxytocin has been previously reported to induce the performance of short-latency maternal behavior (less than one hour of exposure to foster pups required) in estrogen-treated, ovariectomized virgin rats. Tests for the effect of ICV oxytocin in maternal behavior latency have included transfer of animals from their home cage to a larger test cage one to two hours before oxytocin infusion. The importance of this test feature on peptide-induced short-latency maternal behavior was evaluated by varying the duration of the pre-test cage habituation. The responses of ovariectomized, estrogen-primed Zivic-Miller Sprague-Dawley rats housed in the test cages one week, two hours, or 0 hours before oxytocin or saline infusion were compared. It was found that only the rats given two hours of pre-test cage habituation responded to ICV oxytocin treatment with short-latency maternal behavior. This result is discussed with regard to the failure of other investigators to elicit short-latency maternal behavior with oxytocin. Possible neuroendocrine mechanisms for the interaction of degree of environmental novelty with oxytocin-induced behavior are considered.