From Chemical Topology to Molecular Machines
From Chemical Topology to Molecular Machines
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DOI：
10.1016/j.crci.2009.10.008
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发表时间：
2010-03
影响因子：
1.6
通讯作者：
J. Sauvage;J. Collin;Stéphanie Durot;J. Frey;V. Heitz;A. Sour;Christian Tock
中科院分区：
文献类型：
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作者：
J. Sauvage;J. Collin;Stéphanie Durot;J. Frey;V. Heitz;A. Sour;Christian Tock
在过去的25年里，具有新型拓扑结构的分子化学得到了爆炸性的发展。这一领域的快速发展在很大程度上源于新的模板合成方法，这种方法使人们能够在真正的宏观水平上制备这些化合物。特别是我们的团队，在早期阶段提出了一种特别高效的铜(I)基模板合成多种链烷和轮烷，参与了分子拓扑结构的复兴。该领域的亮点之一是三叶结的合成，这是一个特别具有挑战性的目标。这个物体不仅是一个美观的分子，而且还显示出与配位化学和手性有关的有趣性质。分子拓扑学的一个很有前途的扩展是分子机器。通过结合链烷和轮烷的特殊性质，即显著的柔韧性和倾向于经历大振幅运动，以及配位化学，已经有可能详细说明和研究各种分子机器。最近的一个例子是一种可调节受体，它基于一个[3]轮烷，连接在两个可移动的卟啉板上。这种化合物和相关分子将导致“分子压力”，并最终导致溶液中可用的分子机器，以催化反应或改变给定底物的构象。
The chemistry of molecules displaying novel topologies has experienced an explosive development in the course of the last 25 years. The fast growth of this field originates to a large extent from the new templated synthetic methods which allow one to prepare these compounds at a real macroscopic level. Our group, in particular, has proposed a particularly efficient copper(I)-based template synthesis of a large variety of catenanes and rotaxanes at an early stage, participating in the revival of molecular topology. One of the highlights of the field has been the synthesis of the trefoil knot, a particularly challenging target. This object is not only an aesthetically attractive molecule but it also displays interesting properties in relation to coordination chemistry and chirality. A highly promising extension of molecular topology is that of molecular machines. By combining the specific properties of catenanes and rotaxanes, i.e., marked flexibility and propensity to undergo large amplitude motions, and coordination chemistry, it has been possible to elaborate and study a large variety of molecular machines. A recent example is that of an adjustable receptor, based on a [3]rotaxane attached to two mobile porphyrinic plates. This compound and related molecules will lead to “molecular presses” and, eventually, to molecular machines usable in solution to catalyse reactions or change the conformation of given substrates.