Transient response of amplified metallothionein genes in CHO cells to induction by alpha interferon.
Transient response of amplified metallothionein genes in CHO cells to induction by alpha interferon.
复制标题
CHO 细胞中扩增的金属硫蛋白基因对 α 干扰素诱导的瞬时反应。
DOI：
10.1128/mcb.7.2.600-605.1987
复制
发表时间：
1987
影响因子：
5.3
通讯作者：
Huang,PC
中科院分区：
文献类型：
--
作者：
Morris,S;Huang,PC
Alpha interferon treatment of CHO cells elicits the rapid synthesis of many gene products, including metallothionein (MT), a protein which avidly binds heavy metals such as zinc, cadmium, and copper. Since MTs appear to have a pleiotropic role in the cell, ranging from metal detoxification to free-radical scavenging, interferon treatment may trigger a generalized defense mechanism. Activation by interferon, however, was transient, with MT mRNA being maximally detectable by a cytodot procedure within the first hour. Subsequent addition of interferon was ineffective until 7 h after the initial treatment. The action of zinc, a potent inducer of MT, however, remained independent of alpha interferon induction. The transient nature of induction by interferon was examined for altered rate of MT mRNA turnover.
