Relationship between short telomere length and stroke: A meta-analysis.
Relationship between short telomere length and stroke: A meta-analysis.
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DOI：
10.1097/md.0000000000012489
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发表时间：
2018-09
期刊：
影响因子：
1.6
通讯作者：
Xu D
中科院分区：
文献类型：
--
作者：
Jin X;Pan B;Dang X;Wu H;Xu D
在不同的人群队列中进行了几项流行病学研究，以估计端粒长度缩短与中风的关系。然而，结果仍然存在争议。因此，我们进行了这一元分析，以估计它们之间的关系。系统地搜索PubMed、EMBASE和Web of Science的相关文章，以评估“中风”和“端粒长度”之间的关联。采用STATA12.0软件进行Meta分析。采用Cochran q检验和不一致指数(I2)评价异质性。采用Begg漏斗图和Egger检验评价发表偏倚。这项荟萃分析由11项研究组成，共有25,340名参与者。我们发现端粒缩短与卒中显著相关(OR：1.5 0，95%CI：1.13~2.0；P = .0 0 5)，但在前瞻性和回顾性研究亚组中，我们没有发现端粒缩短与卒中有统计学意义的关系(前瞻性亚组：OR：1.4 1，95%CI：1~1.98；P = .0 5 1)(回顾亚组：OR：1.89，95%CI：0.96~3.72；P = .067)。
Several epidemiological studies had been carried out in different population cohorts to estimate the relationship between the shortened telomere length and stroke. However, the results still remained dispute. Consequently, we conducted this meta-analysis to estimate the relationship between them. PubMed, EMBASE, and Web of Science were systematically searched for related articles to evaluate the association between “stroke” and “telomere length. STATA 12.0 software was used to perform the meta-analysis. The Cochran Q test and inconsistency index (I2) were used to assess the heterogeneity. Begg funnel plot and Egger test were used to assess publication bias. The meta-analysis was composed of 11 studies, consisting of 25,340 participants. We found a significant relationship between shortened telomere length and stroke (OR: 1.50, 95% CI: 1.13–2.0; P = .005); however, in the prospective and retrospective study subgroup, we did not find a statistical significant relationship between shortened telomere length and stroke (the prospective subgroup: OR: 1.41, 95% CI: 1–1.98; P = .051) (the retrospective subgroup: OR: 1.89, 95% CI: 0.96–3.72; P = .067).