Impact of loop statistics on the thermodynamics of RNA folding
Impact of loop statistics on the thermodynamics of RNA folding
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DOI：
10.1103/physrevlett.101.048103
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发表时间：
2008-07-25
影响因子：
8.6
通讯作者：
Netz, Roland R.
中科院分区：
文献类型：
--
作者：
Einert, Thomas R.;Naeger, Paul;Netz, Roland R.
环在天然RNA结构中是丰富的，并且在接近解折叠转变时增殖。通过包括一个统计权重类似于l（-c）的循环长度l的递归关系的分区函数，我们表明，热容量敏感地依赖于指数c的存在和值，即使是一个短的明确的tRNA序列。对于长的同源RNA，我们解析计算的临界温度和临界指数表现出非普适依赖于c。
Loops are abundant in native RNA structures and proliferate close to the unfolding transition. By including a statistical weight similar to l(-c) for loops of length l in the recursion relation for the partition function, we show that the heat capacity depends sensitively on the presence and value of the exponent c, even for a short explicit tRNA sequence. For long homo-RNA, we analytically calculate the critical temperature and critical exponents which exhibit a nonuniversal dependence on c.