INVIVO TESTS OF THE CONCEPT OF PHOTODYNAMIC THRESHOLD DOSE IN NORMAL RAT-LIVER PHOTOSENSITIZED BY ALUMINUM CHLOROSULFONATED PHTHALOCYANINE
INVIVO TESTS OF THE CONCEPT OF PHOTODYNAMIC THRESHOLD DOSE IN NORMAL RAT-LIVER PHOTOSENSITIZED BY ALUMINUM CHLOROSULFONATED PHTHALOCYANINE
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DOI：
10.1111/j.1751-1097.1990.tb01720.x
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发表时间：
1990-03-01
影响因子：
3.3
通讯作者：
GRAFF, R
中科院分区：
文献类型：
--
作者：
PATTERSON, MS;WILSON, BC;GRAFF, R
在其最简单的形式中，光动力治疗（PDT）阈值剂量模型指出，如果每单位体积组织中光敏剂吸收的光子数超过临界值，则会发生PDT导致的组织坏死。该阈值由光子注量、光敏剂浓度和比吸收系数的乘积给出。为了测试这个概念的有效性PDT或正常大鼠肝脏敏化铝氯磺化酞菁（AISPC），所有这三个参数的变化，通过改变注射的AISPC剂量，激发波长和照射几何。由处理引起的坏死程度与阈值模型一致，除了当肝脏中AISPC的浓度超过20 μ g g-1时。对于该动物模型，我们估计阈值为（3.8 . ±. 0.2). times. 1019光子cm-3。
In its simplests form, the photodynamic therapy (PDT) threshold dose model states that tissue necrosis due to PDT will occur if the number of photons absorbed by the photosensitizer per unit volume of tissue exceeds a critical value. This threshold is given by the product of photon fluence, photosensitizer concentration and specific absorption coefficient. To test the validity of this concept for PDT or normal rat liver sensitized with aluminium chlorosulphonated phthalocyanine (AISPC), all three of these parameters were varied by changing the injected AISPC dose, the wavelength of excitation and the irradiation geometry. The extent of necrosis caused by the treatment was consistent with the threshold model, except when the concentration of AISPC in the liver exceeded 20 .mu.g g-1. For this animal model, we estimate the threshold to be (3.8 .+-. 0.2) .times. 1019 photons cm-3.