BENEFICIAL 6-YEAR OUTCOME OF SMOKING CESSATION IN OLDER MEN AND WOMEN WITH CORONARY-ARTERY DISEASE - RESULTS FROM THE CASS REGISTRY
BENEFICIAL 6-YEAR OUTCOME OF SMOKING CESSATION IN OLDER MEN AND WOMEN WITH CORONARY-ARTERY DISEASE - RESULTS FROM THE CASS REGISTRY
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DOI：
10.1056/nejm198811243192101
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发表时间：
1988-11-24
影响因子：
158.5
通讯作者：
GERSH, BJ
中科院分区：
文献类型：
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作者：
HERMANSON, B;OMENN, GS;GERSH, BJ
我们研究了吸烟和戒烟对来自冠状动脉外科研究（卡斯）登记处的1893名男性和女性的影响，这些男性和女性年龄在55岁或以上，并有血管造影记录的冠状动脉疾病。持续吸烟者（n = 1086）的6年死亡率高于在研究入组前一年戒烟并在研究期间戒烟的人（n = 807）（相对风险，1.7 [95%置信限，1.4.，2.0]）。持续吸烟者发生心肌梗死或死亡的风险也较高（1.5 [1.2，1.7]）。随着年龄的增长，有益效果没有减少。55 - 64岁组和65岁或以上组的死亡相对风险分别为1.7（1.4，2.1）和1.6（1.1，2.3），35 - 54岁卡斯受试者中可比亚组的死亡相对风险为1.6（1.4，1.9）。当受试者根据风险四分位数排列时，戒烟的好处在中等风险的人中最大。我们的结论是，戒烟降低了老年人和年轻人冠状动脉疾病的死亡或心肌梗死的风险。
We investigated the effects of cigarette smoking and cessation of smoking in a cohort of 1893 men and women from the Coronary Artery Surgery Study (CASS) registry who were 55 years of age or older and had angiographically documented coronary artery disease. The six-year mortality rate was greater among continuing smokers (n = 1086) than among those who quit smoking during the year before enrollment in the study and abstained through the study (n = 807) (relative risk, 1.7 [95 percent confidence limits, 1.4., 2.0]). Continuing smokers were also at higher risk of either myocardial infarction or death (1.5 [1.2, 1.7]). There was no diminution of the beneficial effect with increasing age. The relative risks of death were 1.7 (1.4, 2.1) and 1.6 (1.1, 2.3) for the groups 55 to 64 years old and 65 or older, respectively, and 1.6 (1.4, 1.9) for comparable subgroups among CASS subjects 35 to 54 years of age. When subjects were arrayed according to risk quartile, the benefits of smoking cessation were greatest in those at moderate risk. We conclude that smoking cessation lessens the risk of death or myocardial infarction in older as well as younger persons with coronary artery disease.