The silicon trypanosome: a test case of iterative model extension in systems biology.
The silicon trypanosome: a test case of iterative model extension in systems biology.
复制标题
DOI：
10.1016/b978-0-12-800143-1.00003-8
复制
发表时间：
2014
影响因子：
--
通讯作者：
Breitling R
中科院分区：
文献类型：
--
作者：
Achcar F;Fadda A;Haanstra JR;Kerkhoven EJ;Kim DH;Leroux AE;Papamarkou T;Rojas F;Bakker BM;Barrett MP;Clayton C;Girolami M;Krauth-Siegel RL;Matthews KR;Breitling R
布氏锥虫（Trypanosoma brucei）是一种单细胞寄生虫，引起非洲锥虫病（人类昏睡病和动物长虫病）。由于其独特的性质，它已成为系统生物学中流行的模式生物。一个预测性的定量模型糖酵解的血流形式的寄生虫已经构建和更新了几次。SilicoTryposome（SilicoTryp）是一个项目，汇集了建模者和实验者，以改进和扩展这一核心模型，并提供新的途径和额外的监管水平。这些新的扩展和分析使用的计算方法，明确考虑到不同程度的不确定性。在这个项目中，许多工具和技术已经为此目的开发，现在可以用于系统生物学的各种不同的研究。
The African trypanosome, Trypanosoma brucei, is a unicellular parasite causing African Trypanosomiasis (sleeping sickness in humans and nagana in animals). Due to some of its unique properties, it has emerged as a popular model organism in systems biology. A predictive quantitative model of glycolysis in the bloodstream form of the parasite has been constructed and updated several times. The Silicon Trypanosome (SilicoTryp) is a project that brings together modellers and experimentalists to improve and extend this core model with new pathways and additional levels of regulation. These new extensions and analyses use computational methods that explicitly take different levels of uncertainty into account. During this project, numerous tools and techniques have been developed for this purpose, which can now be used for a wide range of different studies in systems biology.