Pharmacological Management of Obesity: An Endocrine Society Clinical Practice Guideline
Pharmacological Management of Obesity: An Endocrine Society Clinical Practice Guideline
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DOI：
10.1210/jc.2014-3415
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发表时间：
2015-02-01
影响因子：
5.8
通讯作者：
Still, Christopher D.
中科院分区：
文献类型：
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作者：
Apovian, Caroline M;Aronne, Louis J.;Still, Christopher D.
目的：制定肥胖药物治疗的临床实践指南。参与者：内分泌学会指定的专家工作组、方法学家和医学作家。这份指南是由欧洲内分泌学学会和肥胖学会共同发起的。证据：这份循证指南是使用建议分级、评估、发展和评估(等级)系统来描述建议的力度和证据的质量。协商过程：一次小组会议、几次电话会议和电子邮件通信使共识成为可能。内分泌学会、欧洲内分泌学学会和肥胖学会的委员会和成员审查并评论了这些指南的初稿。两个系统的综述总结了一些支持的证据。结论：对于有肥胖相关危险因素和合并症的患者来说，减肥是改善健康的途径。对于那些单独节食和锻炼不成功的患者来说，被批准用于慢性体重管理的药物可以成为改变生活方式的有用的辅助手段。许多通常用于治疗糖尿病、抑郁症和其他慢性病的药物都有体重效应，要么是为了促进体重增加，要么是为了减肥。有知识的药物处方，尽可能选择那些体重状况良好的药物，可以帮助预防和管理肥胖，从而改善健康。
Objective: To formulate clinical practice guidelines for the pharmacological management of obesity.Participants: An Endocrine Society-appointed Task Force of experts, a methodologist, and a medical writer. This guideline was co-sponsored by the European Society of Endocrinology and The Obesity Society.Evidence: This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe the strength of recommendations and the quality of evidence.Consensus Process: One group meeting, several conference calls, and e-mail communications enabled consensus. Committees and members of the Endocrine Society, the European Society of Endocrinology, and The Obesity Society reviewed and commented on preliminary drafts of these guidelines. Two systematic reviews were conducted to summarize some of the supporting evidence.Conclusions: Weight loss is a pathway to health improvement for patients with obesity-associated risk factors and comorbidities. Medications approved for chronic weight management can be useful adjuncts to lifestyle change for patients who have been unsuccessful with diet and exercise alone. Many medications commonly prescribed for diabetes, depression, and other chronic diseases have weight effects, either to promote weight gain or produce weight loss. Knowledgeable prescribing of medications, choosing whenever possible those with favorable weight profiles, can aid in the prevention and management of obesity and thus improve health.