Inflammation and immunity in diseases of the arterial tree: players and layers.
Inflammation and immunity in diseases of the arterial tree: players and layers.
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DOI：
10.1161/circresaha.116.301313
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发表时间：
2015-01-16
影响因子：
20.1
通讯作者：
Hansson GK
中科院分区：
文献类型：
--
作者：
Libby P;Hansson GK
免疫和炎症参与血管疾病发病机制的假说现在得到了广泛的认可，并刺激了全球的工作。随着知识的拓宽，对免疫和炎症机制的作用的认识已经扩展到动脉的所有层，延伸到动脉树的所有层面，并几乎涉及到所有的手臂、细胞“玩家”以及这些关键的宿主防御所涉及的效应器分子和通路，这些防御在疾病中反过来对我们不利。我们在此提供一系列论文概要的指南，旨在展望并拓宽动脉疾病免疫发病机制的传统焦点，目标是整合涉及的“玩家”和“层”。虽然该领域取得了显著进展，但仍有许多工作要做，本文还旨在强调未来研究在炎症和免疫参与动脉疾病方面应努力弥合的一些差距。
The hypothesis that immunity and inflammation participate in the pathogenesis of vascular diseases has now gained widespread recognition and stimulated work around the globe. Broadening knowledge has extended the recognition of the role of immune and inflammatory mechanisms to all of the layers of the artery, to all levels of the arterial tree, and implicated virtually all arms, cellular “players,” and effector molecules and pathways involved in these crucial host defenses, that turn against us in disease. We provide here a guide to a compendium series of papers that aimed to look forward, and broaden the traditional focus of immunopathogenesis of arterial disease, with the goal of integrating the “players” and the “layers” involved. While the field has advanced remarkably, much remains to be done, and this commentary also aims to highlight some of the gaps that future research should strive to close regarding the participation of inflammation and immunity in arterial diseases.