Willingness to participate in HIV-1 vaccine trials among young Thai men
Willingness to participate in HIV-1 vaccine trials among young Thai men
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DOI：
10.1136/sti.76.5.386
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发表时间：
2000-10-01
影响因子：
3.6
通讯作者：
Nitayaphan, S
中科院分区：
文献类型：
--
作者：
Jenkins, RA;Torugsa, K;Nitayaphan, S
目的：对2670名泰国皇家陆军新兵进行了参加HIV-1疫苗试验的意愿及其相关因素的调查。在HIV-1流行病学纵向队列研究的最后一次访视期间收集数据。横断面分析的数据，从这次访问performed.Results：32%的人回答说，他们会“肯定”加入HIV-1疫苗试验。更大的意愿与感知的HIV-1感染风险和帮助泰国社会的愿望有关，尽管在疫苗试验中减少安全套使用的有形激励措施和意图也与意愿增加有关。对身体伤害的担忧和预期来自家庭的不愿加入的社会压力是阻碍自愿加入的最大障碍。关注“社会危害”（践踏，参与会出现艾滋病病毒，合作伙伴可能会拒绝性）也出现抑制兴趣加入试验和接近significance.Conclusions：愿意参加是有点大于其他调查的非注射吸毒者（IDU）队列在泰国，较少的关注表示对身体的伤害。动机似乎涉及感知风险，预期的社会压力，利他主义和有形奖励之间的权衡。到目前为止，疫苗试验没有出现重大问题，沿着研究中存在教育干预，这可能有助于解释相对于其他泰国研究，这里的关注程度较低。
Objectives: Willingness to participate in HIV-1 vaccine trials and associated factors were investigated in a sample of 2670 Royal Thai Army conscripted recruits.Methods: Self administered questionnaires were used. Data were collected during the final visit of a longitudinal cohort study of HIV-1 epidemiology. Cross sectional analysis of data from this visit was performed.Results: 32% of che respondents reported they would "definitely" join an HIV-1 Vaccine trial. Greater willingness was associated with perceived risk of HIV-1 infection and a desire to help Thai society, although tangible incentives and intentions to reduce condom use in a vaccine trial also were associated with increased willingness. Concerns about physical harm and anticipated social pressure from family not to join were the most substantial impediments to willingness. Concerns about "social harm" (for trample, participation would give appearance of having AIDS virus, a partner might refuse sex) also appeared to inhibit interest in joining trials and approached significance.Conclusions: Willingness to participate was somewhat greater than in other investigations of non-injection drug user (IDU) cohorts in Thailand, with fewer concerns expressed about physical harm. Motivations appear to involve tradeoffs among perceived risk, anticipated social pressure, altruism, and tangible rewards. The absence of significant problems associated with vaccine trials to date, along with the presence of educational interventions in the study may help explain the lower level of concerns here relative to other Thai studies.