Study protocol for WHO and UNICEF estimates of global, regional, and national preterm birth rates for 2010 to 2019.
Study protocol for WHO and UNICEF estimates of global, regional, and national preterm birth rates for 2010 to 2019.
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DOI：
10.1371/journal.pone.0258751
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Moran AC
中科院分区：
文献类型：
--
作者：
De Costa A;Moller AB;Blencowe H;Johansson EW;Hussain-Alkhateeb L;Ohuma EO;Okwaraji YB;Cresswell J;Requejo JH;Bahl R;Oladapo OT;Lawn JE;Moran AC
早产是五岁以下儿童死亡的主要原因。此前的估计显示，2014年全球早产率为10.6%（1480万新生儿）。我们的目标是更新2010年至2019年期间全球、区域和国家层面的早产估计数。早产定义为在37个完整的妊娠周之前，或自女性末次月经后<259天发生的活产。将检索最近一年内机构出生率≥80%的WHO会员国的国家行政数据来源。如果≥80%的联合国估计活产包括定义早产的胎龄信息，则将考虑这些国家确定的管理数据。对于没有合格管理数据的国家，将对研究进行系统性审查。如果报告的结果来自在国家或次国家层面在基于人群或机构的环境中进行的观察性或干预性研究，则研究将符合资格。偏倚风险评估将侧重于胎龄测量方法和覆盖范围，以及在已发表的估计值中纳入特殊亚组。将根据与早产、数据可用性和许多国家和年份的协变量数据质量之间合理关联的概念框架，先验选择纳入的协变量。将使用贝叶斯多级混合回归模型估计全球、区域和国家早产率。在许多国家，由于国家行政来源的数据不完整或不可用，加上怀孕期间界定早产的胎龄评估有限，因此准确测量早产具有挑战性。最新的模型估计将是衡量全球早产负担的重要资源，并为政策和计划提供信息，特别是在新生儿死亡率高的环境中。PROSPERO注册号：CRD 42021237861。
Preterm birth is a leading cause of death among children under five years. Previous estimates indicated global preterm birth rate of 10.6% (14.8 million neonates) in 2014. We aim to update preterm birth estimates at global, regional, and national levels for the period 2010 to 2019. Preterm birth is defined as a live birth occurring before 37 completed gestational weeks, or <259 days since a woman’s last menstrual period. National administrative data sources for WHO Member States with facility birth rates of ≥80% in the most recent year for which data is available will be searched. Administrative data identified for these countries will be considered if ≥80% of UN estimated live births include gestational age information to define preterm birth. For countries without eligible administrative data, a systematic review of studies will be conducted. Research studies will be eligible if the reported outcome is derived from an observational or intervention study conducted at national or sub-national level in population- or facility-based settings. Risk of bias assessments will focus on gestational age measurement method and coverage, and inclusion of special subgroups in published estimates. Covariates for inclusion will be selected a priori based on a conceptual framework of plausible associations with preterm birth, data availability, and quality of covariate data across many countries and years. Global, regional and national preterm birth rates will be estimated using a Bayesian multilevel-mixed regression model. Accurate measurement of preterm birth is challenging in many countries given incomplete or unavailable data from national administrative sources, compounded by limited gestational age assessment during pregnancy to define preterm birth. Up-to-date modelled estimates will be an important resource to measure the global burden of preterm birth and to inform policies and programs especially in settings with a high burden of neonatal mortality. PROSPERO registration: CRD42021237861.