PHOTOPHYSICAL STUDIES OF BACTERIOCHLOROPHYLL-A AND BACTERIOPHEOPHYTIN-A - SINGLET OXYGEN GENERATION
PHOTOPHYSICAL STUDIES OF BACTERIOCHLOROPHYLL-A AND BACTERIOPHEOPHYTIN-A - SINGLET OXYGEN GENERATION
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DOI：
10.1016/1011-1344(87)80009-x
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发表时间：
1987-09-01
影响因子：
5.4
通讯作者：
LAND, EJ
中科院分区：
文献类型：
--
作者：
BORLAND, CF;MCGARVEY, DJ;LAND, EJ
在几种环境中，细菌叶绿体和细菌叶绿体都能产生大量光敏单线态氧。细菌叶绿素的三重态量子产额略低于细菌叶绿素，但单线态氧的量子产额相当接近。这两种细菌色素与单线态氧的反应非常有效，二级速率常数接近扩散控制的极限。这些结果从细菌色素三重态能级和细菌系统作为“第二代”光敏剂用于癌症光动力治疗的可能性进行了讨论。
Both bacteriochlorophyllaand bacteriopheophytinalead to a substantial photosensitized yield of singlet oxygen in several environments. The triplet quantum yields of bacteriochlorophyllain non-deuterated solvents are somewhat lower than those of bacteriopheophytinabut the singlet oxygen quantum yields are rather similar. Both bacterial pigments react very efficiently with singlet oxygen with second-order rate constants near the diffusion-controlled limit. These results are discussed with respect to the bacterial pigment triplet energy level and the possible use of bacterial systems as “second generation” photosensitizers for photodynamic therapy of cancer.