Impact of overweight on the risk of developing common chronic diseases during a 10-year period
Impact of overweight on the risk of developing common chronic diseases during a 10-year period
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DOI：
10.1001/archinte.161.13.1581
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发表时间：
2001-07-09
影响因子：
--
通讯作者：
Colditz, GA
中科院分区：
文献类型：
--
作者：
Field, AE;Coakley, EH;Colditz, GA
背景：超重的成年人患多种慢性疾病的风险增加。方法：对护士健康研究中的中年女性和健康专业人员随访研究中的男性进行十年随访（1986-1996），以评估与超重相关的健康风险。结果：无论男女，患糖尿病、胆结石、高血压、心脏病和中风的风险都随着超重的严重程度而增加。与体重指数 (BMI)（以公斤体重除以米身高平方计算）在 18.5 至 24.9 之间的同性同性相比，BMI 为 35.0 或更高的人患糖尿病的可能性高出约 20 倍（相对风险 [RR]，17.0；女性的 95% 置信区间 [CI]，14.2-20.5；RR，23.4； 95% CI，男性 19.4-33.2）。超重但不肥胖的女性（即 BMI 在 25.0 至 29.9 之间）也比较瘦的同龄人更容易患胆结石（RR，1.9）、高血压（RR，1.7）、高胆固醇水平（RR，1.1）和心脏病（RR，1.4）。男性的结果相似。结论：在10年的随访期间，无论男性还是女性，糖尿病、胆结石、高血压、心脏病、结肠癌和中风（仅限男性）的发病率均随着超重程度的增加而增加。超重但不肥胖（即 25.0 小于或等于 BMI 小于或等于 29.9）的成年人患多种健康状况的风险显着增加。此外，即使在健康体重范围的上半部分（即BMI为22.0-24.9）的成年人中，BMI与患慢性病风险之间的剂量反应关系也很明显，这表明成年人应尽量将BMI维持在18.5至21.9之间，以尽量减少患病风险。
Background: Overweight adults are at an increased risk of developing numerous chronic diseases.Methods: Ten-year follow-up (1986-1996) of middle-aged women in the Nurses' Health Study and men in the Health Professionals Follow-up Study to assess the health risks associated with overweight.Results: The risk of developing diabetes, gallstones, hypertension, heart disease, and stroke increased with severity of overweight among both women and men. Compared with their same-sex peers with a body mass index (BMI) (calculated as weight in kilograms divided by the square of height in meters) between 18.5 and 24.9, those with BMI of 35.0 or more were approximately 20 times more likely to develop diabetes (relative risk [RR], 17.0; 95% confidence interval [CI], 14.2-20.5 for women; RR, 23.4; 95% CI, 19.4-33.2 for men). Women who were overweight but not obese (ie, BMI between 25.0 and 29.9) were also significantly more likely than their leaner peers to develop gallstones (RR, 1.9), hypertension (RR, 1.7), high cholesterol level (RR, 1.1), and heart disease (RR, 1.4). The results were similar in men.Conclusions: During 10 years of follow-up, the incidence of diabetes, gallstones, hypertension, heart disease, colon cancer, and stroke (men only) increased with degree of overweight in both men and women. Adults who were overweight but not obese (ie, 25.0 less than or equal to BMI less than or equal to 29.9) were at significantly increased risk of developing numerous health conditions. Moreover, the dose-response relationship between BMI and the risk of developing chronic diseases was evident even among adults in the upper half of the healthy weight range (ie, BMI of 22.0-24.9), suggesting that adults should try to maintain a BMI between 18.5 and 21.9 to minimize their risk of disease.