Perivascular astrocytes within Alzheimer's disease plaques
Perivascular astrocytes within Alzheimer's disease plaques
复制标题
DOI：
10.1097/00001756-199705260-00033
复制
发表时间：
1997-05-27
期刊：
影响因子：
1.7
通讯作者：
Cullen, KM
中科院分区：
文献类型：
--
作者：
Cullen, KM
星形胶质细胞与斑块的联系是阿尔茨海默病(AD)的一个公认的特征，通常被解释为对淀粉样蛋白沉积或神经元变性的二次反应。用增强免疫组织化学方法对6例AD患者和6例非痴呆对照组的大脑皮质、基底前脑、杏仁核、壳核和间脑的星形胶质细胞进行了研究。AD组和对照组脑组织星形胶质细胞与弥漫性和非弥漫性斑块共存。所有与斑块相关的星形胶质细胞都接触到微血管，尽管有更多肥大和细口径的突起，这些细胞仍保持着对照脑组织特有的血管周围排列。这些观察表明，斑块形成于微血管畸形的部位，随后血管周围星形胶质细胞发生反应性和退行性改变。
THE association of astrocytes with plaques is a well-established feature of Alzheimer's disease (AD) and has generally been interpreted as a secondary reaction to amyloid deposition or neuronal degeneration. Astrocytes in brain tissue from six non-demented controls and six patients with AD were investigated using enhanced immunohistochemistry for glial fibrillary acid protein (GFAP) in serial sections from cortex, basal forebrain, amygdala, putamen and diencephalon. Astrocytes colocalized with all diffuse and non-diffuse plaques in AD and control brain tissue. All plaque-associated astrocytes contacted microvessels, and despite having greater numbers of hypertrophic and fine calibre processes, the cells maintained the perivascular arrangement characteristic of control brain tissue. These observations suggest that plaques form at the site of microvascular aberrations followed by reactive and degenerative changes in perivascular astrocytes.