Plasma Carotenoids and Biomarkers of Oxidative Stress in Patients with prior Head and Neck Cancer.
Plasma Carotenoids and Biomarkers of Oxidative Stress in Patients with prior Head and Neck Cancer.
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DOI：
10.4137/bmi.s2192
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发表时间：
2009-03-23
影响因子：
3.8
通讯作者：
Cartmel B
中科院分区：
文献类型：
--
作者：
Hughes KJ;Mayne ST;Blumberg JB;Ribaya-Mercado JD;Johnson EJ;Cartmel B
富含水果和蔬菜的饮食通常被认为可以预防几种慢性疾病。一种建议的机制是减少氧化应激。类胡萝卜素是在有色水果和蔬菜中发现的营养素，在体外具有抗氧化特性，但它们在人体中的作用却没有得到很好的证明。本横断面研究的目的是探索最丰富的血浆类胡萝卜素（α-胡萝卜素，β-胡萝卜素，番茄红素，叶黄素，玉米黄质和β-隐黄质），以及分组类胡萝卜素（总叶黄素，胡萝卜素和类胡萝卜素），和尿排泄的F2-异前列烷（F2-IsoPs），脂质氧化损伤的稳定和特异性生物标志物之间的关系。使用两种F2-IsoP测量：总F2-IsoP和8-iso-PGF 2 α。研究人群（N = 52）来自一项在早期头颈癌患者中进行的治愈性治疗研究。未经调整的线性回归分析显示，血浆叶黄素，总叶黄素和两个F2-IsoP措施在基线显着负相关。在控制了潜在的混杂因素后，所有个体和分组的叶黄素与F2-IsoP测量呈负相关，但这些相关性均无显著性。胡萝卜素与总F2-IsoPs或8-iso-PGF 2a浓度不呈负相关。个体和分组叶黄素，但不是个体和分组胡萝卜素，和F2-IsoPs之间一致的逆关联的发现是有趣的，值得进一步研究。
Diets high in fruits and vegetables are generally believed protective against several chronic diseases. One suggested mechanism is a reduction in oxidative stress. The carotenoids, nutrients found in colored fruits and vegetables, possess antioxidant properties in vitro, but their role in humans is less well documented. The aim of this cross-sectional study was to explore the relationships between the most abundant plasma carotenoids (alpha-carotene, beta-carotene, lycopene, lutein, zeaxanthin and beta-cryptoxanthin), as well as grouped carotenoids (total xanthophylls, carotenes and carotenoids), and urinary excretion of the F2-isoprostanes (F2-IsoPs), stable and specific biomarkers of oxidative damage to lipids. Two F2-IsoP measures were utilized: total F2-IsoPs and 8-iso-PGF2α. The study population (N = 52) was drawn from a study among patients curatively treated for early-stage head and neck cancer. Unadjusted linear regression analyses revealed significant inverse associations between plasma lutein, total xanthophylls and both F2-IsoP measures at baseline. After control for potential confounders, all individual and grouped xanthophylls remained inversely associated with the F2-IsoP measures, but none of these associations achieved significance. The carotenes were not inversely associated with total F2-IsoPs or 8-iso-PGF2a concentrations. The finding of consistent inverse associations between individual and grouped xanthophylls, but not individual and grouped carotenes, and F2-IsoPs is intriguing and warrants further investigation.