Testicular disruption in the As (aspermia) mutant rat, with special reference to the aggregate of ribosomes.
Testicular disruption in the As (aspermia) mutant rat, with special reference to the aggregate of ribosomes.
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As（无精症）突变体大鼠的睾丸破坏，特别是核糖体聚集。
DOI：
--
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发表时间：
1993
影响因子：
1.2
通讯作者：
Y. Hayashi
中科院分区：
文献类型：
--
作者：
Y. Atagi;H. Ikadai;M. Kurohmaru;Y. Hayashi
本研究对精子发生严重中断的突变AS(无精症)品系大鼠的睾丸形态进行了研究。精子发生的最高级发育是在第8步，此时精子细胞具有基本定向的顶体。生精小管内多见圆形精细胞来源的多核巨细胞。形态和镧示踪研究证实，相邻支持细胞之间的血-睾丸屏障功能正常。光镜观察发现粗线期精母细胞内有一种特殊的结构，由许多直径约25 nm的颗粒组成。经组织化学和电子显微镜研究，该结构为核糖体聚集体。粗线期前的未成熟生精细胞、支持细胞和间质区均未见明显异常。AS突变大鼠的睾丸破坏可能是由于粗线期精母细胞蛋白质合成途径异常所致。
The morphology of the testis of the mutant As (aspermia) strain rat with severely interrupted spermatogenesis was investigated in the present study. The most advanced development in spermatogenesis was observed at the step 8 at which spermatids had basally-oriented acrosomes. Multinucleate giant cells derived from round spermatids were frequently encountered within the seminiferous tubules. The functionally normal status of the blood-testis barrier between adjacent Sertoli cells was confirmed by morphological and lanthanum tracer studies. By light microscopy, a peculiar structure was found within the pachytene spermatocyte, consisting of numerous particles of approximately 25 nm in diameter. By histochemical and electron microscopic studies, this structure was identified as an aggregate of ribosomes. Neither immature spermatogenic cells up to the pachytene phase, nor Sertoli cells nor interstitial regions showed a recognizable abnormality. It seems that the testicular disruption in the As mutant rat is due to the abnormality in the protein synthetic pathway in pachytene spermatocytes.
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sys（共生精子细胞）小鼠的睾丸结构。
DOI：
10.1002/aja.1001920206
发表时间：
1991
期刊：
The American journal of anatomy
影响因子：
--
作者：
Russell,LD;Hikim,AP;Overbeek,PA;MacGregor,GR
通讯作者：
MacGregor,GR
症状性精子细胞（sys）：小鼠的隐性插入突变，导致精子发生缺陷。
DOI：
10.1073/pnas.87.13.5016
发表时间：
1990
影响因子：
11.1
作者：
MacGregor,GR;Russell,LD;VanBeek,ME;Hanten,GR;Kovac,MJ;Kozak,CA;Meistrich,ML;Overbeek,PA
通讯作者：
Overbeek,PA
哺乳动物精子发生过程中的基因表达。
影响因子：
3.6
作者：
Stern,L;Gold,B;Hecht,NB
通讯作者：
Hecht,NB
基因定义的男性不育小鼠模型。
影响因子：
--
作者：
Chubb,C
通讯作者：
Chubb,C
影响因子：
--
作者：
MEISTRICH, ML;TROSTLEWEIGE, PK;RUSSELL, LD
通讯作者：
RUSSELL, LD