Salmon roe-like amyloid deposition in a prolactinoma: a case report
Salmon roe-like amyloid deposition in a prolactinoma: a case report
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催乳素瘤中鲑鱼子样淀粉样蛋白沉积：病例报告
DOI：
10.1007/bf02483453
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发表时间：
2006
影响因子：
3.3
通讯作者：
T. Yoshimoto
中科院分区：
文献类型：
--
作者：
T. Hassan;H. Ikeda;T. Yoshimoto
本文报告一例罕见的泌乳素腺瘤伴广泛淀粉样蛋白沉积的病例，以阐明其影像学、术中、光镜和电镜所见。一位41岁女性患者主诉持续闭经20年。磁共振成像（MRI）显示垂体腺瘤，其中包括T1和T2加权图像上的低强度斑点。术中检查发现腺瘤内有多个小的、黄色的、类似鲑鱼卵的球形肿块。光学和电子显微镜显示泌乳素的免疫反应细胞的存在下，与同心层状体的放射状排列的淀粉样纤维起源于内质网的催乳素瘤细胞。细胞外层状淀粉样蛋白沉积显然是由于泌乳素产生细胞的降解，但淀粉样蛋白的产生和放射状排列的积累的原因仍有待确定。
An unusual case of prolactin-producing adenoma with extensive amyloid deposition is reported to clarify its radiological, intraoperative, and light- and electron-microscopic findings. A 41-year-old female patient complained of amenorrhea persisting for 20 years. Magnetic resonance imaging (MRI) revealed a pituitary adenoma, which included low-intensity spots on T1- and T2-weighted images. Intraoperative examination found multiple small, yellowish, spherical masses resembling salmon roe within the adenoma. Light and electron microscopy revealed the presence of immunoreactive cells for prolactin intermingled with concentric lamellar bodies of radially arranged amyloid fibrils originating from the endoplasmic reticulum in prolactinoma cells. The extracellular lamellar amyloid deposits were apparently due to degradation of prolactin-producing cells, but the reason for the production and radially arranged accumulation of amyloid remains to be identified.