Tissue factor initiated blood coagulation
Tissue factor initiated blood coagulation
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DOI：
10.2741/1888
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发表时间：
2006-05-01
影响因子：
3.1
通讯作者：
McVey, JH
中科院分区：
文献类型：
--
作者：
Gomez, K;McVey, JH
Tissue factor (TF) is the cellular receptor and cofactor for blood coagulation factor (F) VII.流动的血液暴露于表达 TF 的细胞会导致血液凝固的开始。血液凝固受到严格调节，可在血管损伤部位产生局部纤维蛋白凝块，而不会影响脉管系统中的血流。本章描述了反应的启动和传播，以及最终如何下调反应以防止广泛的不适当的血液凝固。
Tissue factor (TF) is the cellular receptor and cofactor for blood coagulation factor (F) VII. Exposure of flowing blood to cells that express TF leads to the initiation of blood coagulation. Blood coagulation is tightly regulated to generate a local fibrin clot at the site of vascular injury without compromising blood flow in the vasculature. This chapter describes the initiation and propagation of the response and how it is ultimately down-regulated to prevent widespread inappropriate blood coagulation.