Review—Catalytic Electrochemical Biosensors for Dopamine: Design, Performance, and Healthcare Applications
Review—Catalytic Electrochemical Biosensors for Dopamine: Design, Performance, and Healthcare Applications
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DOI：
10.1149/2754-2726/ad3950
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发表时间：
2024-04
期刊：
影响因子：
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通讯作者：
Emily DeVoe;Silvana Andreescu
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文献类型：
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作者：
Emily DeVoe;Silvana Andreescu
多巴胺是日常认知功能的必需神经递质，控制许多神经生理过程，包括记忆、认知和身体控制。开发检测多巴胺的分析方法和传感器对于健康监测和神经学研究非常重要。本文综述了基于酶和酶模拟材料的电化学催化生物传感器的最新进展，并讨论了它们在生物流体中多巴胺测量中的潜在应用。综述的第一部分总结和批判性地评估了不同类型的酶和酶模拟材料，可用于催化转化多巴胺，其次是讨论生物传感器的制造，关键设计参数，和各种电极平台上的检测机制，从一次性使用的丝网印刷电极微针和植入式微电极。第二部分提供了生物样品中多巴胺测量的例子，包括唾液，尿液，血清，细胞培养物和脑组织。最后，我们总结了这些设备在临床领域的优势和局限性，并展望了未来的研究，实现和更广泛地采用电化学生物传感器在神经生理学，药理学和临床领域。
Dopamine is an essential neurotransmitter for daily cognitive functions controlling many neurophysiological processes including memory, cognition, and physical control. Development of analytical methods and sensors to detect dopamine is important for health monitoring and neurological research. This review provides an overview of recent advances in the development of electrochemical catalytic biosensors based on enzyme and enzyme-mimetic materials and discusses their potential applications for measurements of dopamine in biological fluids. The first part of the review summarizes and critically assesses the different types of enzymes and enzyme mimetic materials that can be used to catalytically convert dopamine, followed by a discussion of the biosensor’s fabrication, key design parameters, and detection mechanism on various electrode platforms ranging from single-use screen-printed electrodes to microneedles and implantable microelectrodes. The second part provides examples of measurements of dopamine in biological samples, including saliva, urine, serum, cell cultures, and brain tissue. We conclude with a summary of advantages and limitations of these devices in the clinical field, and an outlook to future research towards the implementation and broader adoption of electrochemical biosensors in neurophysiology, pharmacology, and the clinical field.