Adenovirus in a synthetic membrane wrapper: an example of hybrid vigor?
Adenovirus in a synthetic membrane wrapper: an example of hybrid vigor?
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DOI：
10.1021/nn800279s
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发表时间：
2008-05
期刊：
影响因子：
17.1
通讯作者：
D. Thompson
中科院分区：
文献类型：
--
作者：
D. Thompson
核酸递送应用需要开发有效、选择性和无毒的载体系统。已经研究了许多不同的病毒和非病毒方法，包括逆转录病毒、腺病毒、脂质体和树枝状聚合物的使用。不幸的是，这些运载工具的安全性和效率仍然存在问题。在本视角中，强调了设计能够进行有效基因治疗的稳定载体的挑战。还介绍了该领域的进展，包括 Kostarelos 及其同事在本期《ACS Nano》中的工作，他们在其中描述了一种由包裹病毒纳米粒子的脂质包膜组成的新型递送载体。
Nucleic acid delivery applications require the development of carrier systems that are effective, selective, and non-toxic. Many different viral and non-viral approaches, including the use of retroviruses, adenoviruses, liposomes, and dendrimers, have been investigated. Unfortunately, issues still remain with regard to the safety and efficiency of these delivery vehicles. In this Perspective, the challenges of designing a stable vector that is capable of effective gene therapy are highlighted. Progress in the area is also presented, including the work of Kostarelos and co-workers appearing in this issue of ACS Nano, in which they describe a novel delivery vehicle that consists of lipid envelopes encasing viral nanoparticles.